TY - JOUR
T1 - Effect of occlusal (mechanical) stimulus on bone remodelling in rat mandibular condyle
AU - Gazit, D.
AU - Ehrlich, J.
AU - Kohen, Y.
AU - Bab, I.
PY - 1987/9
Y1 - 1987/9
N2 - Gazit D, Ehrlich J, Kohen Y, Bab I. Effect of occlusal (mechanical) stimulus on bone remodelling in rat mandibular condyle. J Oral Pathol 1987: 16: 395–398. Mechanical load influences the remodelling of skeletal tissues. In the mandibular condyle, occlusal alterations and the consequent mechanical stimulus induce changes in chondrocytes and cartilage mineralization. In the present study we quantified in the mandibular condyle the effect of occlusal interference on remodelling of the subchondral bone. Computerized histomorphometry after 5–21‐day exposure to the influence of a unilateral occlusal splint revealed an increased rate of trabecular remodelling, consisting of enhancement in osteoblast and osteoclast numbers and activities. The bone formation parameters reached their high values on Days 5 or 9 and remained stable thereafter. Bone resorption showed a gradual increase throughout the experimental period. These results further characterize the temporomandibular joint reaction to occlusal alterations. It is suggested that the present increase in bone turnover together with the known enhancement in chondrogenesis are part of a process of functional adaptation in response to mechanical stimulus.
AB - Gazit D, Ehrlich J, Kohen Y, Bab I. Effect of occlusal (mechanical) stimulus on bone remodelling in rat mandibular condyle. J Oral Pathol 1987: 16: 395–398. Mechanical load influences the remodelling of skeletal tissues. In the mandibular condyle, occlusal alterations and the consequent mechanical stimulus induce changes in chondrocytes and cartilage mineralization. In the present study we quantified in the mandibular condyle the effect of occlusal interference on remodelling of the subchondral bone. Computerized histomorphometry after 5–21‐day exposure to the influence of a unilateral occlusal splint revealed an increased rate of trabecular remodelling, consisting of enhancement in osteoblast and osteoclast numbers and activities. The bone formation parameters reached their high values on Days 5 or 9 and remained stable thereafter. Bone resorption showed a gradual increase throughout the experimental period. These results further characterize the temporomandibular joint reaction to occlusal alterations. It is suggested that the present increase in bone turnover together with the known enhancement in chondrogenesis are part of a process of functional adaptation in response to mechanical stimulus.
UR - http://www.scopus.com/inward/record.url?scp=0023412362&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0714.1987.tb02072.x
DO - 10.1111/j.1600-0714.1987.tb02072.x
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C2 - 3121824
AN - SCOPUS:0023412362
SN - 0904-2512
VL - 16
SP - 395
EP - 398
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
IS - 8
ER -