TY - JOUR
T1 - Effect of physostigmine on morphine-induced postoperative pain and somnolence
AU - Weinstock, M.
AU - Davidson, J. T.
AU - Rosin, A. J.
AU - Schnieden, H.
PY - 1982/4
Y1 - 1982/4
N2 - The effects of physostigmine 1 mg I V were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10mg/60kg 1 v in 10 patients recovering from surgery. Within 5-10min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values Analgesia, assessed by an independent observer and by the patient was, if anything, increased by physostigmine. The analeptic effect of physostigmine lasted 40-60 min.
AB - The effects of physostigmine 1 mg I V were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10mg/60kg 1 v in 10 patients recovering from surgery. Within 5-10min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values Analgesia, assessed by an independent observer and by the patient was, if anything, increased by physostigmine. The analeptic effect of physostigmine lasted 40-60 min.
UR - http://www.scopus.com/inward/record.url?scp=0020070848&partnerID=8YFLogxK
U2 - 10.1093/bja/54.4.429
DO - 10.1093/bja/54.4.429
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C2 - 7066140
AN - SCOPUS:0020070848
SN - 0007-0912
VL - 54
SP - 429
EP - 434
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 4
ER -