Effect of physostigmine on morphine-induced postoperative pain and somnolence

M. Weinstock; J. T. Davidson; A. J. Rosin; H. Schnieden

doi:10.1093/bja/54.4.429

Effect of physostigmine on morphine-induced postoperative pain and somnolence

M. Weinstock^*
, J. T. Davidson
, A. J. Rosin
, H. Schnieden

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The effects of physostigmine 1 mg I V were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10mg/60kg 1 v in 10 patients recovering from surgery. Within 5-10min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values Analgesia, assessed by an independent observer and by the patient was, if anything, increased by physostigmine. The analeptic effect of physostigmine lasted 40-60 min.

Original language	English
Pages (from-to)	429-434
Number of pages	6
Journal	British Journal of Anaesthesia
Volume	54
Issue number	4
DOIs	https://doi.org/10.1093/bja/54.4.429
State	Published - Apr 1982

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abstract = "The effects of physostigmine 1 mg I V were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10mg/60kg 1 v in 10 patients recovering from surgery. Within 5-10min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values Analgesia, assessed by an independent observer and by the patient was, if anything, increased by physostigmine. The analeptic effect of physostigmine lasted 40-60 min.",

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Effect of physostigmine on morphine-induced postoperative pain and somnolence

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