Effect of PLGA block molecular weight on gelling temperature of PLGA-PEG-PLGA thermoresponsive copolymers

Noam Y. Steinman; Moran Haim-Zada; Isaac A. Goldstein; Ayelet H. Goldberg; Tom Haber; Jacob M. Berlin; Abraham J. Domb

doi:10.1002/pola.29275

Effect of PLGA block molecular weight on gelling temperature of PLGA-PEG-PLGA thermoresponsive copolymers

Noam Y. Steinman, Moran Haim-Zada, Isaac A. Goldstein, Ayelet H. Goldberg, Tom Haber, Jacob M. Berlin, Abraham J. Domb^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Thermoresponsive, biodegradable polymeric hydrogel networks are used widely in medicinal applications. Poly(d,l-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(d,l-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymers exhibit a sol–gel transition upon heating. The effect of PLGA block and PEG chain molecular weights (MWs) on the gelling temperature of polymer aqueous solution (20% w/w) is described. All polymer solutions convert into a hard gel within 2 °C of the gelling temperature. The release properties of the gels were displayed using paracetamol as a representative drug. A linear relation is described between the gelling temperature and PLGA block MW.

Original language	English
Pages (from-to)	35-39
Number of pages	5
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	57
Issue number	1
DOIs	https://doi.org/10.1002/pola.29275
State	Published - 1 Jan 2019

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Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

Keywords

PEG-PLGA
biodegradable polymers
copolymerization
drug delivery systems
hydrogels
thermoresponsive hydrogels

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10.1002/pola.29275

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title = "Effect of PLGA block molecular weight on gelling temperature of PLGA-PEG-PLGA thermoresponsive copolymers",

abstract = "Thermoresponsive, biodegradable polymeric hydrogel networks are used widely in medicinal applications. Poly(d,l-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(d,l-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymers exhibit a sol–gel transition upon heating. The effect of PLGA block and PEG chain molecular weights (MWs) on the gelling temperature of polymer aqueous solution (20\% w/w) is described. All polymer solutions convert into a hard gel within 2 °C of the gelling temperature. The release properties of the gels were displayed using paracetamol as a representative drug. A linear relation is described between the gelling temperature and PLGA block MW.",

keywords = "PEG-PLGA, biodegradable polymers, copolymerization, drug delivery systems, hydrogels, thermoresponsive hydrogels",

author = "Steinman, \{Noam Y.\} and Moran Haim-Zada and Goldstein, \{Isaac A.\} and Goldberg, \{Ayelet H.\} and Tom Haber and Berlin, \{Jacob M.\} and Domb, \{Abraham J.\}",

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year = "2019",

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doi = "10.1002/pola.29275",

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AU - Steinman, Noam Y.

AU - Haim-Zada, Moran

AU - Goldstein, Isaac A.

AU - Goldberg, Ayelet H.

AU - Haber, Tom

AU - Berlin, Jacob M.

AU - Domb, Abraham J.

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AB - Thermoresponsive, biodegradable polymeric hydrogel networks are used widely in medicinal applications. Poly(d,l-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(d,l-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymers exhibit a sol–gel transition upon heating. The effect of PLGA block and PEG chain molecular weights (MWs) on the gelling temperature of polymer aqueous solution (20% w/w) is described. All polymer solutions convert into a hard gel within 2 °C of the gelling temperature. The release properties of the gels were displayed using paracetamol as a representative drug. A linear relation is described between the gelling temperature and PLGA block MW.

KW - PEG-PLGA

KW - biodegradable polymers

KW - copolymerization

KW - drug delivery systems

KW - hydrogels

KW - thermoresponsive hydrogels

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IS - 1

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Effect of PLGA block molecular weight on gelling temperature of PLGA-PEG-PLGA thermoresponsive copolymers

Abstract

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Keywords

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