TY - JOUR
T1 - Effect of salt acclimation on digitalis-like compounds in the toad
AU - Lichtstein, David
AU - Gati, Irith
AU - Babila, Tamar
AU - Haver, Eitan
AU - Katz, Uri
PY - 1991/1/23
Y1 - 1991/1/23
N2 - Digitalis-like compounds (DLC) were shown to be a normal constituent of the skin and plasma of toads. In order to assess the possible physiological role of these compounds in the toad, their levels were determined in the brain, plasma and skin following acclimation in different NaCl solutions. We demonstrate that an increase in salt concentrations in the animal medium from 0 to 1.2% decreased the levels of DLC in the brain by 50% without altering significantly its levels in the plasma and skin. An increase in medium salt concentration to 1.5% resulted in a 50% increase of DLC levels in the skin without changing its levels in the plasma or brain. These results suggest that skin and brain DLC may participate in the long-term salt and water homeostasis in the toad, while the plasma compound either participates in the short-term regulations of salt and water homeostasis or have some other, unknown, function.
AB - Digitalis-like compounds (DLC) were shown to be a normal constituent of the skin and plasma of toads. In order to assess the possible physiological role of these compounds in the toad, their levels were determined in the brain, plasma and skin following acclimation in different NaCl solutions. We demonstrate that an increase in salt concentrations in the animal medium from 0 to 1.2% decreased the levels of DLC in the brain by 50% without altering significantly its levels in the plasma and skin. An increase in medium salt concentration to 1.5% resulted in a 50% increase of DLC levels in the skin without changing its levels in the plasma or brain. These results suggest that skin and brain DLC may participate in the long-term salt and water homeostasis in the toad, while the plasma compound either participates in the short-term regulations of salt and water homeostasis or have some other, unknown, function.
KW - Amphibian skin
KW - ATPase, Na, K-
KW - Digitalis-like compound
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=0026030637&partnerID=8YFLogxK
U2 - 10.1016/0304-4165(91)90183-H
DO - 10.1016/0304-4165(91)90183-H
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C2 - 1991148
AN - SCOPUS:0026030637
SN - 0304-4165
VL - 1073
SP - 65
EP - 68
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
IS - 1
ER -