Effect of salt on the formation of salt-bridges in β-hairpin peptides

Shahar Sukenik, Yoav Boyarski, Daniel Harries*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Salt-bridges ubiquitously form between oppositely charged moieties in proteins. Here we quantify changes in population of salt-bridged β-hairpin peptides due to added salt, and determine the thermodynamic driving forces and cooperativity of salt-bridge formation under these conditions. We find only a fraction of salt-bridged folded conformations at physiologically relevant salt concentrations.

Original languageAmerican English
Pages (from-to)8193-8196
Number of pages4
JournalChemical Communications
Volume50
Issue number60
DOIs
StatePublished - 1 Jul 2014

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