Effect of spontaneous diffusion in micro/nanoporous chemically crosslinked poly (N-vinyl imidazole) gel on the conformational changes of acetylcholine

Evgenia Vaganova*, Ines F. Pierola, Haim Ovadia, Sergey E. Lyshevski, Shlomo Yitzchaik

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Interdependent structural properties such as molecular conformation, flexibility and charge redistribution control the intermolecular interactions of acetylcholine (ACh) with adjacent molecules. This paper reports the results of an investigation of the effect of the diffusion of ACh through a nano/microporous poly (N-vinylimidazole) (PVI) gel on its structural properties, namely on changes in its conformation. To investigate the conformational changes of ACh during spontaneous diffusion through the gel, the fluorescence lifetime of the label molecule - fluorescein - was monitored. To clarify the results, analogous experiments were conducted with nicotinic acid and dopamine. In contrast to the nicotinic acid and dopamine, ACh can play the role of a regulator in molecular transport.

Original languageAmerican English
Title of host publicationSingle Molecule Spectroscopy and Imaging II
DOIs
StatePublished - 2009
EventSingle Molecule Spectroscopy and Imaging II - San Jose, CA, United States
Duration: 24 Jan 200925 Jan 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7185
ISSN (Print)1605-7422

Conference

ConferenceSingle Molecule Spectroscopy and Imaging II
Country/TerritoryUnited States
CitySan Jose, CA
Period24/01/0925/01/09

Keywords

  • ACh
  • Diffusion
  • Fluorescence lifetime
  • Neurotransmitter molecules
  • Porous gel

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