Abstract
The effect of sustained-release on the pharmacokinetics of theophylline was examined by comparing two sustained-release formulations (Theo-Dur® and Theotard®) to an oral solution and i.v. preparation of the drug. Drug-level monitoring was performed by an HPLC assay. The absorption profiles of the three oral formulations were pharmacokinetically analyzed by using the Loo-Riegelman procedure. The absorption of theophylline after the administration of the Theo-Dur® and Theotard® was found to be of an apparent zero-order kinetics.
| Original language | English |
|---|---|
| Pages (from-to) | 662-667 |
| Number of pages | 6 |
| Journal | International Journal of Clinical Pharmacology Therapy and Toxicology |
| Volume | 23 |
| Issue number | 12 |
| State | Published - 1985 |