Effect of tension on pore formation in drug-containing vesicles

Cheryl Li Weakliem; Gary Fujii; Joan En Chang; Avinoam Ben-Shaul; William M. Gelbart

doi:10.1021/j100019a057

Effect of tension on pore formation in drug-containing vesicles

Cheryl Li Weakliem^*, Gary Fujii, Joan En Chang, Avinoam Ben-Shaul, William M. Gelbart

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Pore formation in unilamellar lipid vesicles is believed to occur when the concentration of membrane-bound drug molecules exceeds a certain value. We treat this phenomenon in analogy with that of the micellization of surfactant in bulk aqueous solutions, thereby relating the threshold concentration of drug molecules to the free energy associated with transferring a molecule to a pore from its uniformly-dispersed state in the membrane. Incorporating the effects of lateral tension induced by osmotic pressure, we calculate the lowering of the pore-formation threshold with increasing tension. These predictions are tested by direct measurements on liposomal dispersions involving the antifungal drug amphotericin B.

Original language	English
Pages (from-to)	7694-7697
Number of pages	4
Journal	Journal of Physical Chemistry
Volume	99
Issue number	19
DOIs	https://doi.org/10.1021/j100019a057
State	Published - 1995

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title = "Effect of tension on pore formation in drug-containing vesicles",

abstract = "Pore formation in unilamellar lipid vesicles is believed to occur when the concentration of membrane-bound drug molecules exceeds a certain value. We treat this phenomenon in analogy with that of the micellization of surfactant in bulk aqueous solutions, thereby relating the threshold concentration of drug molecules to the free energy associated with transferring a molecule to a pore from its uniformly-dispersed state in the membrane. Incorporating the effects of lateral tension induced by osmotic pressure, we calculate the lowering of the pore-formation threshold with increasing tension. These predictions are tested by direct measurements on liposomal dispersions involving the antifungal drug amphotericin B.",

author = "Weakliem, {Cheryl Li} and Gary Fujii and Chang, {Joan En} and Avinoam Ben-Shaul and Gelbart, {William M.}",

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AU - Chang, Joan En

AU - Ben-Shaul, Avinoam

AU - Gelbart, William M.

PY - 1995

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AB - Pore formation in unilamellar lipid vesicles is believed to occur when the concentration of membrane-bound drug molecules exceeds a certain value. We treat this phenomenon in analogy with that of the micellization of surfactant in bulk aqueous solutions, thereby relating the threshold concentration of drug molecules to the free energy associated with transferring a molecule to a pore from its uniformly-dispersed state in the membrane. Incorporating the effects of lateral tension induced by osmotic pressure, we calculate the lowering of the pore-formation threshold with increasing tension. These predictions are tested by direct measurements on liposomal dispersions involving the antifungal drug amphotericin B.

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Effect of tension on pore formation in drug-containing vesicles

Abstract

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