Effect of zinc ions on the synthesis of herpes simplex virus DNA in infected BSC-1 cells

Joseph Shlomai; Yael Asher; Yitzhak J. Gordon; Udy Olshevsky; Yechiel Becker

doi:10.1016/0042-6822(75)90204-4

Effect of zinc ions on the synthesis of herpes simplex virus DNA in infected BSC-1 cells

Joseph Shlomai^*
, Yael Asher
, Yitzhak J. Gordon
, Udy Olshevsky
, Yechiel Becker

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Treatment of herpes simplex virus-infected cells with ZnSO₄ (0.2 mM) inhibited the synthesis of viral DNA. A similar concentration of ZnSO₄ had no effect on DNA synthesis in uninfected cells. In vitro analyses revealed a marked depression of the DNA-polymerase activity in nuclei obtained from zinc-treated infected cells.

Original language	English
Pages (from-to)	330-335
Number of pages	6
Journal	Virology
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(75)90204-4
State	Published - Jul 1975

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title = "Effect of zinc ions on the synthesis of herpes simplex virus DNA in infected BSC-1 cells",

abstract = "Treatment of herpes simplex virus-infected cells with ZnSO4 (0.2 mM) inhibited the synthesis of viral DNA. A similar concentration of ZnSO4 had no effect on DNA synthesis in uninfected cells. In vitro analyses revealed a marked depression of the DNA-polymerase activity in nuclei obtained from zinc-treated infected cells.",

author = "Joseph Shlomai and Yael Asher and Gordon, \{Yitzhak J.\} and Udy Olshevsky and Yechiel Becker",

year = "1975",

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AU - Olshevsky, Udy

AU - Becker, Yechiel

PY - 1975/7

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N2 - Treatment of herpes simplex virus-infected cells with ZnSO4 (0.2 mM) inhibited the synthesis of viral DNA. A similar concentration of ZnSO4 had no effect on DNA synthesis in uninfected cells. In vitro analyses revealed a marked depression of the DNA-polymerase activity in nuclei obtained from zinc-treated infected cells.

AB - Treatment of herpes simplex virus-infected cells with ZnSO4 (0.2 mM) inhibited the synthesis of viral DNA. A similar concentration of ZnSO4 had no effect on DNA synthesis in uninfected cells. In vitro analyses revealed a marked depression of the DNA-polymerase activity in nuclei obtained from zinc-treated infected cells.

UR - https://www.scopus.com/pages/publications/0016527183

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AN - SCOPUS:0016527183

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VL - 66

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JO - Virology

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Effect of zinc ions on the synthesis of herpes simplex virus DNA in infected BSC-1 cells

Abstract

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