Effects of amlodipine, captopril, and bezafibrate on oxidative milieu in rats with fatty liver

Zvi Ackerman*, Mor Oron-Herman, Talma Rosenthal, Orit Pappo, Gabriela Link, Ben Ami Sela, Maria Grozovski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Oxidative stress may initiate significant hepatocyte injury in subjects with fatty liver. We characterized changes in hepatic oxidative anti-oxidative parameters in rats given a fructose-enriched diet (FED) with and without medications to reduce blood pressure or plasma triglycerides. FED rats had an increase in malondialdehyde (MDA) concentration, a reduction in α-tocopherol concentration, a reduction in paraoxonase (PON) activity, an increase in glutathione peroxidase (GSH-Px), and glutathione reductase (GSSG-R) activity. Amlodipine increased PON and GSH-Px, but decreased GSSG-R activity and α-tocopherol concentration. Captopril decreased MDA concentration and the activity of both GSH-Px and GSSG-R, but increased α-tocopherol concentration and PON activity. Bezafibrate increased α-tocopherol concentration and PON activity, but decreased the activity of GSSG-R. Animals with fatty liver exhibit an increase in peroxidative stress but also a defect in anti-oxidative pathways. Drugs administered to treat hypertension and hypertriglyceridemia could lead to a variety of changes in the hepatic oxidative, anti-oxidative milieu.

Original languageAmerican English
Pages (from-to)777-784
Number of pages8
JournalDigestive Diseases and Sciences
Volume53
Issue number3
DOIs
StatePublished - Mar 2008

Keywords

  • Alpha-tocopherol
  • Amlodipine
  • Bezafibrate
  • Captopril
  • Glutathione peroxidase and reductase
  • Malondialdehyde
  • Paraoxonase

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