Effects of an oral hygiene regimen on progression of gingivitis/early periodontitis: A randomized controlled trial

Avraham Zini, Sigal Mazor, Hans Timm, Matthew L. Barker, Julie M. Grender, Robert W. Gerlach, Aaron R. Biesbrock*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Periodontal disease continues to be prevalent globally, but little clinical research has been undertaken to evaluate the long-term benefits of a daily oral hygiene regimen on progression of gingivitis/early periodontitis. The objective of this study was to evaluate the effects of an oral hygiene regimen (OHR) on the periodontal health of adults in good general health with established gingivitis and early periodontitis over 24 months. Methods: A randomized controlled trial was conducted in adults with established gingivitis, with isolated sites of probing pocket depth >4 mm. Study participants were randomized to the OHR (bioavailable stannous fluoride dentifrice, oscillating-rotating electric toothbrush, cetylpyridinium chloride rinse, and floss; P&G) or usual care products (sodium fluoride dentifrice and manual toothbrush; P&G) groups. At baseline and every 6 months, gingivitis and periodontal measures were assessed and a prophylaxis was conducted. The primary outcome was Gingival Bleeding Index–Bleeding Sites (GBI–BS). Analyses used ANCOVA at 5% significance levels. Results: A total of 107 individuals were enrolled; 87 completed the study. Mean GBI–BS, Modified Gingival Index, and Probing Pocket Depth (PPD) scores were significantly lower at each visit for the OHR versus usual care group by 28% to 39%, 12% to 18%, and 6% to 13%, respectively (p ≤ 0.0009). The magnitude of reduction in median number of ≥2 mm PPD loss events for OHR versus the usual care group at 24 months was 74%. Conclusion: Long-term use of the OHR produced significant periodontal health improvements versus the usual care products.

Original languageAmerican English
Pages (from-to)85-94
Number of pages10
JournalCanadian Journal of Dental Hygiene
Issue number2
StatePublished - 1 Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 Canadian Dental Hygienists Association.


  • Cetylpyridinium chloride
  • Dental floss
  • Gingivitis
  • Oral hygiene
  • Periodontal diseases
  • Stannous fluoride


Dive into the research topics of 'Effects of an oral hygiene regimen on progression of gingivitis/early periodontitis: A randomized controlled trial'. Together they form a unique fingerprint.

Cite this