Effects of dexamethasone on TNF-alpha-induced released of cytokines from purified human blood eosinophils

Iain Uings, Ilaria Puxeddu, Vladislav Temkin, Susan J. Smith, Dilniya Fattah, Keith P. Ray, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: TNF-alpha is an important mediator in allergy also for its effects on eosinophils. Methods: The effect of dexamethasone on TNF-alpha induced eosinophils survival, degranulation (ECP), cytokines release (IL-8, GM-CSF) and adhesion to VCAM-I, ICAM-I and IgG coated wells (EPO release) were evaluated. Results: The drug inhibited IL-8 and GM-CSF production, but not viability, degranulation or adhesion in human peripheral blood eosinophils. Conclusion: These results indicate that part of the activity of glucocorticosteroids on eosinophils may be mediated by their ability to inhibit cytokine secretion that in turn is important for the perpetuation of the allergic inflammation.

Original languageEnglish
Article number5
JournalClinical and Molecular Allergy
Volume3
DOIs
StatePublished - 27 Apr 2005

Keywords

  • Allergic inflammation
  • Cytokine
  • Dexamethasone
  • Eosinophils
  • TNF-α

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