Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins - The Jerusalem Nutrition Study. II Monounsaturated fatty acids vs carbohydrates

Elliot M. Berry*, Shlomo Eisenberg, Yechiel Friedlander, Dror Harats, Nathan A. Kaufmann, Yehudit Norman, Yechezkiel Stein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

Seventeen male Yeshiva students were randomly allocated to a crossover study with two 12-wk dietary periods of monounsaturated fatty acids (MUFAs) vs a carbohydrate (CHO)-rich diet while concentrations of saturated (SFAs) and polyunsaturated (PUFAs) fatty acids were kept similar. Total plasma cholesterol (TC) decreased significantly by ≈ 7.7% and low-density-lipoprotein cholesterol (LDL-C) by 14.4% on the MUFA diet, whereas on the CHO diet no significant change in cholesterol concentrations occurred, in contrast to that predicted by the equations of Keys and Hegsted. Concentrations of high-density-lipoprotein cholesterol (HDL-C) did not change significantly on either diet. On the MUFA diet there was a significantly lower proneness to peroxidation of plasma and LDL lipids and less extensive metabolism of conditioned LDL by peritoneal macrophages. We conclude that dietary MUFAs lower TC and LDL-C concentrations, independently of other dietary fatty acids and in addition may reduce the susceptibility of LDL to oxidative stress.

Original languageEnglish
Pages (from-to)394-403
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume56
Issue number2
StatePublished - 1992

Keywords

  • Dietary carbohydrates
  • Dietary fats
  • Fatty acids
  • Lipid peroxidation
  • Lipoproteins
  • Monounsaturated fatty acids

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