Abstract
The effects of fluoride intake on disuse atrophy of the femoral bone were investigated in rats after severing the right sciatic and femoral nerves. X-ray radiograms of the femora were made. Calcium content of the blood, specific gravity, ash percentage and calcium and fluoride content of both femora were determined in operated and non-operated rats drinking distilled or fluoridated (25 ppm) water for 2 months after starting the experiment. The results showed that fluoride counteracts the typical bone atrophy syndrome; it reduces the calcium content of the serum and prevents bone resorption. It is suggested that increased bone resorption is prevented by a reprecipitation of calcium as fluorapatite of low solubility on the surface of the bone crystals. Acknowledgement is made gratefully to Ziporah Pinchevski for technical assistance in this study.
| Original language | English |
|---|---|
| Pages (from-to) | 657-660 |
| Number of pages | 4 |
| Journal | Experimental Biology and Medicine |
| Volume | 122 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1966 |
| Externally published | Yes |
