Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies of tolerance and cross-tolerance

Yehuda Shavit; Gregory W. Terman; James W. Lewis; Cynthia J. Zane; Robert Peter Gale; John C. Liebeskind

doi:10.1016/0006-8993(86)91149-2

Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies of tolerance and cross-tolerance

Yehuda Shavit, Gregory W. Terman, James W. Lewis, Cynthia J. Zane, Robert Peter Gale, John C. Liebeskind^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Exposure to a form of footshock stress known to cause opioid-mediated analgesia suppresses the cytotoxic activity of natural killer (NK) cells in rats. This suppression is blocked by the opioid antagonist, naltrexone and is mimicked by morphine administration, suggesting mediation by opioid receptors. Supporting this hypothesis, we now report that the morphine-induced suppression of NK activity shows tolerance after 14 daily injections. The NK-suppressive effect of stress, however, shows neither tolerance with repetition nor cross-tolerance in morphine-tolerant rats.

Original language	English
Pages (from-to)	382-385
Number of pages	4
Journal	Brain Research
Volume	372
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)91149-2
State	Published - 7 May 1986
Externally published	Yes

Keywords

cross-tolerance
morphine
natural killer cells
opioid peptide
stress
tolerance

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10.1016/0006-8993(86)91149-2

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title = "Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies of tolerance and cross-tolerance",

abstract = "Exposure to a form of footshock stress known to cause opioid-mediated analgesia suppresses the cytotoxic activity of natural killer (NK) cells in rats. This suppression is blocked by the opioid antagonist, naltrexone and is mimicked by morphine administration, suggesting mediation by opioid receptors. Supporting this hypothesis, we now report that the morphine-induced suppression of NK activity shows tolerance after 14 daily injections. The NK-suppressive effect of stress, however, shows neither tolerance with repetition nor cross-tolerance in morphine-tolerant rats.",

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AU - Zane, Cynthia J.

AU - Gale, Robert Peter

AU - Liebeskind, John C.

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AB - Exposure to a form of footshock stress known to cause opioid-mediated analgesia suppresses the cytotoxic activity of natural killer (NK) cells in rats. This suppression is blocked by the opioid antagonist, naltrexone and is mimicked by morphine administration, suggesting mediation by opioid receptors. Supporting this hypothesis, we now report that the morphine-induced suppression of NK activity shows tolerance after 14 daily injections. The NK-suppressive effect of stress, however, shows neither tolerance with repetition nor cross-tolerance in morphine-tolerant rats.

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Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies of tolerance and cross-tolerance

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Keywords

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