Effects of furosemide on the hearing loss induced by impulse noise

Cahtia Adelman, Jeffrey M. Weinberger, Leonid Kriksunov, Haim Sohmer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: The permanent hearing loss following exposure to intense noise can be due either to mechanical structural damage (tearing) caused directly by the noise or to metabolic (biochemical) damage resulting from the elevated levels of free radicals released during transduction of the sound overstimulation. Drugs which depress active cochlear mechanics (e.g. furosemide and salicylic acid) or anti-oxidants (which counteract the free radicals) are effective in reducing the threshold shift (TS) following broadband continuous noise. This study was designed to determine whether furosemide can reduce the TS following exposure to impulse noise, similar to its action with continuous broadband noise. Methods. Shortly after furosemide injection, mice were exposed to simulated M16 rifle impulse noise produced by different loudspeakers and amplifiers in different exposure settings and, in other experiments, also to actual M16 rifle shots. Results: Depending on the paradigm, the simulated noises either did not produce a TS, or the TS was reduced by furosemide. The drug was not effective in reducing TS resulting from actual impulse noise. Conclusion: Simulated M16 rifle impulse noise may not truly replicate the rapid rise time and very high intensity of actual rifle shots so that the TS following exposure to such noise can be reduced by these drugs. On the other hand, actual M16 impulse noise probably causes direct (frank) mechanical damage, which is not reduced by these drugs.

Original languageEnglish
Article number14
JournalJournal of Occupational Medicine and Toxicology
Volume6
Issue number1
DOIs
StatePublished - 2011

Keywords

  • active mechanical displacements
  • cochlear amplifier
  • free radicals
  • furosemide
  • impulse noise
  • noise induced hearing loss
  • outer hair cell motility
  • protection

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