Effects of indomethacin on hematopoiesis in mice

E. Razin; Y. Hayari; A. Globerson

doi:10.1016/0161-4630(81)90122-1

Effects of indomethacin on hematopoiesis in mice

E. Razin^*, Y. Hayari, A. Globerson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effect of indomethacin treatment on hematopoiesis in mice was examined. Twenty-four hours following the onset of treatment there was 3-fold increase in bone marrow non-specific esterase positive cells (NEPC) as compared to the initial level. Two days later a two-fold increase in spleen and peritoneal NEPC was observed.In all the organs examined, NEPC returned to its basal level after cessation of treatment. The increase in number of NEPC was accompanied by an elevation in CSF production. The effect of indomethacin on peripheral blood cells was also determined. A significant decrease in hematocrit level was found following the treatment. In addition, it was further found that following the drug treatment there was a significant reduction of erythrocyte number and hemoglobin levels.

Original language	English
Pages (from-to)	613-620
Number of pages	8
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0161-4630(81)90122-1
State	Published - Jun 1981
Externally published	Yes

Keywords

CM, conditioned medium
CSF, colonies stimulating factor
NEPC, non-specific esterase positive cells
PG, prostaglandin

Access to Document

10.1016/0161-4630(81)90122-1

Cite this

@article{8098ba168cf348319c22f37c6724b6db,

title = "Effects of indomethacin on hematopoiesis in mice",

abstract = "The effect of indomethacin treatment on hematopoiesis in mice was examined. Twenty-four hours following the onset of treatment there was 3-fold increase in bone marrow non-specific esterase positive cells (NEPC) as compared to the initial level. Two days later a two-fold increase in spleen and peritoneal NEPC was observed.In all the organs examined, NEPC returned to its basal level after cessation of treatment. The increase in number of NEPC was accompanied by an elevation in CSF production. The effect of indomethacin on peripheral blood cells was also determined. A significant decrease in hematocrit level was found following the treatment. In addition, it was further found that following the drug treatment there was a significant reduction of erythrocyte number and hemoglobin levels.",

keywords = "CM, conditioned medium, CSF, colonies stimulating factor, NEPC, non-specific esterase positive cells, PG, prostaglandin",

author = "E. Razin and Y. Hayari and A. Globerson",

year = "1981",

month = jun,

doi = "10.1016/0161-4630(81)90122-1",

language = "אנגלית",

volume = "6",

pages = "613--620",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

issn = "0161-4630",

publisher = "Churchill Livingstone",

number = "6",

}

TY - JOUR

T1 - Effects of indomethacin on hematopoiesis in mice

AU - Razin, E.

AU - Hayari, Y.

AU - Globerson, A.

PY - 1981/6

Y1 - 1981/6

N2 - The effect of indomethacin treatment on hematopoiesis in mice was examined. Twenty-four hours following the onset of treatment there was 3-fold increase in bone marrow non-specific esterase positive cells (NEPC) as compared to the initial level. Two days later a two-fold increase in spleen and peritoneal NEPC was observed.In all the organs examined, NEPC returned to its basal level after cessation of treatment. The increase in number of NEPC was accompanied by an elevation in CSF production. The effect of indomethacin on peripheral blood cells was also determined. A significant decrease in hematocrit level was found following the treatment. In addition, it was further found that following the drug treatment there was a significant reduction of erythrocyte number and hemoglobin levels.

AB - The effect of indomethacin treatment on hematopoiesis in mice was examined. Twenty-four hours following the onset of treatment there was 3-fold increase in bone marrow non-specific esterase positive cells (NEPC) as compared to the initial level. Two days later a two-fold increase in spleen and peritoneal NEPC was observed.In all the organs examined, NEPC returned to its basal level after cessation of treatment. The increase in number of NEPC was accompanied by an elevation in CSF production. The effect of indomethacin on peripheral blood cells was also determined. A significant decrease in hematocrit level was found following the treatment. In addition, it was further found that following the drug treatment there was a significant reduction of erythrocyte number and hemoglobin levels.

KW - CM, conditioned medium

KW - CSF, colonies stimulating factor

KW - NEPC, non-specific esterase positive cells

KW - PG, prostaglandin

UR - http://www.scopus.com/inward/record.url?scp=0019493876&partnerID=8YFLogxK

U2 - 10.1016/0161-4630(81)90122-1

DO - 10.1016/0161-4630(81)90122-1

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 6973765

AN - SCOPUS:0019493876

SN - 0161-4630

VL - 6

SP - 613

EP - 620

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 6

ER -

Effects of indomethacin on hematopoiesis in mice

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this