Effects of indomethacin treatment on human peripheral blood monocytes

Indomethacin treatment (3-8 daily doses of 100 mg) to patients resulted in an increased level of peripheral blood monocytes, as compared to the initial values measured in each individual subject before taking the drug. Normal levels were resumed after the treatment stopped. The idea that these observations were related to the drug treatment per se and not superimposed by the arthritis was verified by the fact that similar results were obtained in healthy volunteers taking this drug.