Effects of larval rearing substrates on some life-table parameters of lutzomyia longipalpis sand flies

Kelsilandia Aguiar Martins*, Maria Helena de Athayde Meirelles, Tiago Feitosa Mota, Ibrahim Abbasi, Artur Trancoso Lopo de Queiroz, Claudia Ida Brodskyn, Patrícia Sampaio Tavares Veras, Deborah Bittencourt Mothé Fraga, Alon Warburg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Sand flies are the insects responsible for transmitting Leishmania parasites, the causative agents of leishmaniasis in humans. However, the effects of sand fly breeding sites on their biology and ecology remain poorly understood. Herein, we studied how larval nutrition associated with putative breeding sites of the sand fly Lutzomyia longipalpis affects their oviposi-tion, development, microbiome, and susceptibility to Leishmania by rearing L. longipalpis on substrates collected from an endemic area for leishmaniasis in Brazil. The results showed that female L. longipalpis select the oviposition site based on its potential to promote larval maturation and while composting cashew leaf litter hindered the development, larvae reared on chicken feces developed rapidly. Typical gut microbial profiles were found in larvae reared upon cashew leaf litter. Adult females from larvae reared on substrate collected in chicken coops were infected with Leishmania infantum, indicating that they were highly sus-ceptible to the parasite. In conclusion, the larval breeding sites can exert an important role in the epidemiology of leishmaniasis.

Original languageAmerican English
Article numbere0009034
Pages (from-to)1-20
Number of pages20
JournalPLoS Neglected Tropical Diseases
Volume15
Issue number1
DOIs
StatePublished - Jan 2021

Bibliographical note

Funding Information:
This study was supported by Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico-CNPq https://www.gov.br/cnpq/pt-br, Grant Number: PVE 401213/2014-5 and 305235 / 2019-2) received by PSTV and Grant Number: 304876/2019-4 by CIB. It was also supported by Funda??o de Amparo ? Pesquisa do Estado da Bahia-FAPESB http://www.fapesb.ba.gov.br/, Grant Number: FAPESB 04/2013, 12/2014 and 04/ 2015 received by CIB. AW received funding from The Israel Science Foundation-https://www.isf.org. il/#/-(Grant Number: 997/19). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2021 Aguiar Martins et al.

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