Effects of prolonged lithium treatment on the water consumption and lithium content of rats

Yael Zilberman; Jaime Kapitulnik; Giora Feuerstein; Dov Lichtenberg

doi:10.1016/S0031-6989(79)80018-1

Effects of prolonged lithium treatment on the water consumption and lithium content of rats

Yael Zilberman^*
, Jaime Kapitulnik
, Giora Feuerstein
, Dov Lichtenberg

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Injection of LiC1 to rats (3.0 mmole/kg/day) caused a marked increase in water intake. The polydipsic effect was maximal after 8 - 10 days of treatment and then gradually declined. This reduction in polydipsia was accompanied by a decrease in Li⁺ content of plasma, red blood cells, liver, spleen, kidney and brain. Furthermore, the ratio of tissue to plasma lithium concentration (lithium index) declined in all tissues examined. The decrease in polydipsia was abolished by increasing the dose of LiC1 by 50%. These results suggest that tolerance to the polydipsic effect of lithium develops in the rat during chronic treatment with LiC1 as a result of a reduction in the cells capacity to accumulate lithium.

Original language	English
Pages (from-to)	467-474
Number of pages	8
Journal	Pharmacological Research Communications
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/S0031-6989(79)80018-1
State	Published - Jun 1979

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title = "Effects of prolonged lithium treatment on the water consumption and lithium content of rats",

abstract = "Injection of LiC1 to rats (3.0 mmole/kg/day) caused a marked increase in water intake. The polydipsic effect was maximal after 8 - 10 days of treatment and then gradually declined. This reduction in polydipsia was accompanied by a decrease in Li+ content of plasma, red blood cells, liver, spleen, kidney and brain. Furthermore, the ratio of tissue to plasma lithium concentration (lithium index) declined in all tissues examined. The decrease in polydipsia was abolished by increasing the dose of LiC1 by 50\%. These results suggest that tolerance to the polydipsic effect of lithium develops in the rat during chronic treatment with LiC1 as a result of a reduction in the cells capacity to accumulate lithium.",

author = "Yael Zilberman and Jaime Kapitulnik and Giora Feuerstein and Dov Lichtenberg",

year = "1979",

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T1 - Effects of prolonged lithium treatment on the water consumption and lithium content of rats

AU - Zilberman, Yael

AU - Kapitulnik, Jaime

AU - Feuerstein, Giora

AU - Lichtenberg, Dov

PY - 1979/6

Y1 - 1979/6

N2 - Injection of LiC1 to rats (3.0 mmole/kg/day) caused a marked increase in water intake. The polydipsic effect was maximal after 8 - 10 days of treatment and then gradually declined. This reduction in polydipsia was accompanied by a decrease in Li+ content of plasma, red blood cells, liver, spleen, kidney and brain. Furthermore, the ratio of tissue to plasma lithium concentration (lithium index) declined in all tissues examined. The decrease in polydipsia was abolished by increasing the dose of LiC1 by 50%. These results suggest that tolerance to the polydipsic effect of lithium develops in the rat during chronic treatment with LiC1 as a result of a reduction in the cells capacity to accumulate lithium.

AB - Injection of LiC1 to rats (3.0 mmole/kg/day) caused a marked increase in water intake. The polydipsic effect was maximal after 8 - 10 days of treatment and then gradually declined. This reduction in polydipsia was accompanied by a decrease in Li+ content of plasma, red blood cells, liver, spleen, kidney and brain. Furthermore, the ratio of tissue to plasma lithium concentration (lithium index) declined in all tissues examined. The decrease in polydipsia was abolished by increasing the dose of LiC1 by 50%. These results suggest that tolerance to the polydipsic effect of lithium develops in the rat during chronic treatment with LiC1 as a result of a reduction in the cells capacity to accumulate lithium.

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JO - Pharmacological Research Communications

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Effects of prolonged lithium treatment on the water consumption and lithium content of rats

Abstract

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