TY - JOUR
T1 - EFFECTS OF VERAPAMIL, DANTROLENE AND LANTHANUM ON CATECHOLAMINE RELEASE FROM RAT ADRENAL MEDULLA
AU - COHEN, JACKIE
AU - GUTMAN, YEHUDA
PY - 1979/4
Y1 - 1979/4
N2 - The release of catecholamines (CA) from rat adrenal incubated in vitro in Locke solution was studied. Acetylcholine‐induced release of CA and CA release by 56 mm KC1 were inhibited by verapamil and lanthanum chloride which block calcium permeability. CA secretion induced by salbutamol or by theophylline was unaffected by either verapamil or lanthanum chloride. Dantrolene‐sodium inhibited the CA secretion induced by theophylline but only partially reduced potassium‐induced release of CA. Verapamil enhanced the secretion of CA induced by salbutamol (in a calcium‐free medium). Tyramine‐induced secretion of CA was unaffected by lanthanum chloride, verapamil or dantrolene‐sodium. It is suggested that cyclic adenosine 3′,5′‐monophosphate‐mediated CA secretion (induced by theophylline or salbutamol) depends on release of calcium from intracellular stores, and that CA secretion induced by tyramine is independent of intra‐ or extracellular calcium. 1979 British Pharmacological Society
AB - The release of catecholamines (CA) from rat adrenal incubated in vitro in Locke solution was studied. Acetylcholine‐induced release of CA and CA release by 56 mm KC1 were inhibited by verapamil and lanthanum chloride which block calcium permeability. CA secretion induced by salbutamol or by theophylline was unaffected by either verapamil or lanthanum chloride. Dantrolene‐sodium inhibited the CA secretion induced by theophylline but only partially reduced potassium‐induced release of CA. Verapamil enhanced the secretion of CA induced by salbutamol (in a calcium‐free medium). Tyramine‐induced secretion of CA was unaffected by lanthanum chloride, verapamil or dantrolene‐sodium. It is suggested that cyclic adenosine 3′,5′‐monophosphate‐mediated CA secretion (induced by theophylline or salbutamol) depends on release of calcium from intracellular stores, and that CA secretion induced by tyramine is independent of intra‐ or extracellular calcium. 1979 British Pharmacological Society
UR - https://www.scopus.com/pages/publications/0018427883
U2 - 10.1111/j.1476-5381.1979.tb07876.x
DO - 10.1111/j.1476-5381.1979.tb07876.x
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C2 - 435689
AN - SCOPUS:0018427883
SN - 0007-1188
VL - 65
SP - 641
EP - 645
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 4
ER -