Efficacy of pulsed dye laser treatment for common warts is not influenced by the causative HPV type: a prospective study

Yoseph Fichman, Assi Levi*, Emmilia Hodak, Shlomit Halachmi, Sigal Mazor, Dana Wolf, Orit Caplan, Moshe Lapidoth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Verruca vulgaris (VV) is a prevalent skin condition caused by various subtypes of human papilloma virus (HPV). The most common causes of non-genital lesions are HPV types 2 and 4, and to a lesser extent types 1, 3, 26, 29, and 57. Although numerous therapeutic modalities exist, none is universally effective or without adverse events (AE). Pulsed dye laser (PDL) is a favorable option due to its observed efficacy and relatively low AE rate. However, it is not known which verrucae are most likely to respond to PDL, or whether the causative viral subtype influences this response. The objective of this prospective blinded study was to assess whether the HPV subtype was predictive of response to PDL. For that matter, 26 verrucae from 26 immunocompetent patients were biopsied prior to treatment by PDL. HPV coding sequences were isolated and genotyped using PCR analysis. Patients were treated by PDL (595 nm wavelength, 5 mm spot size, 1.5 ms pulse duration, 12 J/cm2 fluence) once a month for up to 6 months, and clinical response was assessed. Binary logistic regression analysis and linear logistic regression analysis were used in order to evaluate statistical significance. Different types of HPV were identified in 22 of 26 tissue samples. Response to treatment did not correlate with HPV type, age, or gender. As no association between HPV type and response to PDL therapy could be established, it is therefore equally effective for all HPV types and remains a favorable treatment option for all VV.

Original languageEnglish
Pages (from-to)773-777
Number of pages5
JournalLasers in Medical Science
Volume33
Issue number4
DOIs
StatePublished - 1 May 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017, Springer-Verlag London Ltd., part of Springer Nature.

Keywords

  • HPV
  • Pulsed dye laser
  • Verruca vulgaris
  • Wart

Fingerprint

Dive into the research topics of 'Efficacy of pulsed dye laser treatment for common warts is not influenced by the causative HPV type: a prospective study'. Together they form a unique fingerprint.

Cite this