TY - JOUR
T1 - Efficacy of pulsed dye laser treatment for common warts is not influenced by the causative HPV type
T2 - a prospective study
AU - Fichman, Yoseph
AU - Levi, Assi
AU - Hodak, Emmilia
AU - Halachmi, Shlomit
AU - Mazor, Sigal
AU - Wolf, Dana
AU - Caplan, Orit
AU - Lapidoth, Moshe
N1 - Publisher Copyright:
© 2017, Springer-Verlag London Ltd., part of Springer Nature.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Verruca vulgaris (VV) is a prevalent skin condition caused by various subtypes of human papilloma virus (HPV). The most common causes of non-genital lesions are HPV types 2 and 4, and to a lesser extent types 1, 3, 26, 29, and 57. Although numerous therapeutic modalities exist, none is universally effective or without adverse events (AE). Pulsed dye laser (PDL) is a favorable option due to its observed efficacy and relatively low AE rate. However, it is not known which verrucae are most likely to respond to PDL, or whether the causative viral subtype influences this response. The objective of this prospective blinded study was to assess whether the HPV subtype was predictive of response to PDL. For that matter, 26 verrucae from 26 immunocompetent patients were biopsied prior to treatment by PDL. HPV coding sequences were isolated and genotyped using PCR analysis. Patients were treated by PDL (595 nm wavelength, 5 mm spot size, 1.5 ms pulse duration, 12 J/cm2 fluence) once a month for up to 6 months, and clinical response was assessed. Binary logistic regression analysis and linear logistic regression analysis were used in order to evaluate statistical significance. Different types of HPV were identified in 22 of 26 tissue samples. Response to treatment did not correlate with HPV type, age, or gender. As no association between HPV type and response to PDL therapy could be established, it is therefore equally effective for all HPV types and remains a favorable treatment option for all VV.
AB - Verruca vulgaris (VV) is a prevalent skin condition caused by various subtypes of human papilloma virus (HPV). The most common causes of non-genital lesions are HPV types 2 and 4, and to a lesser extent types 1, 3, 26, 29, and 57. Although numerous therapeutic modalities exist, none is universally effective or without adverse events (AE). Pulsed dye laser (PDL) is a favorable option due to its observed efficacy and relatively low AE rate. However, it is not known which verrucae are most likely to respond to PDL, or whether the causative viral subtype influences this response. The objective of this prospective blinded study was to assess whether the HPV subtype was predictive of response to PDL. For that matter, 26 verrucae from 26 immunocompetent patients were biopsied prior to treatment by PDL. HPV coding sequences were isolated and genotyped using PCR analysis. Patients were treated by PDL (595 nm wavelength, 5 mm spot size, 1.5 ms pulse duration, 12 J/cm2 fluence) once a month for up to 6 months, and clinical response was assessed. Binary logistic regression analysis and linear logistic regression analysis were used in order to evaluate statistical significance. Different types of HPV were identified in 22 of 26 tissue samples. Response to treatment did not correlate with HPV type, age, or gender. As no association between HPV type and response to PDL therapy could be established, it is therefore equally effective for all HPV types and remains a favorable treatment option for all VV.
KW - HPV
KW - Pulsed dye laser
KW - Verruca vulgaris
KW - Wart
UR - http://www.scopus.com/inward/record.url?scp=85037364284&partnerID=8YFLogxK
U2 - 10.1007/s10103-017-2413-5
DO - 10.1007/s10103-017-2413-5
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C2 - 29218494
AN - SCOPUS:85037364284
SN - 0268-8921
VL - 33
SP - 773
EP - 777
JO - Lasers in Medical Science
JF - Lasers in Medical Science
IS - 4
ER -