TY - JOUR
T1 - Efficient Palladium-Catalyzed Coupling of Aryl Chlorides and Tosylates with Terminal Alkynes
T2 - Use of a Copper Cocatalyst Inhibits the Reaction
AU - Gelman, Dmitri
AU - Buchwald, Stephen L.
PY - 2003/12/15
Y1 - 2003/12/15
N2 - Less catalyst, lower temperature, and greater generality are the advantages of the new general protocol over those previously described for the palladium-catalyzed coupling of aryl chlorides and alkynes (see scheme). Better results are obtained without a copper cocatalyst, which has been found to inhibit product formation in the coupling reaction of aryl chlorides with terminal alkynes.
AB - Less catalyst, lower temperature, and greater generality are the advantages of the new general protocol over those previously described for the palladium-catalyzed coupling of aryl chlorides and alkynes (see scheme). Better results are obtained without a copper cocatalyst, which has been found to inhibit product formation in the coupling reaction of aryl chlorides with terminal alkynes.
KW - Alkynes
KW - Aryl chlorides
KW - C-C coupling
KW - Cross-coupling
KW - Palladium
UR - http://www.scopus.com/inward/record.url?scp=0347985383&partnerID=8YFLogxK
U2 - 10.1002/anie.200353015
DO - 10.1002/anie.200353015
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C2 - 14679552
AN - SCOPUS:0347985383
SN - 1433-7851
VL - 42
SP - 5993
EP - 5996
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 48
ER -