Effusion cytology in ovarian cancer: New molecular methods as aids to diagnosis and prognosis

Ben Davidson*, Björn Risberg, Reuven Reich, Aasmund Berner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Carcinoma of the ovary is the leading cause of death from gynecologic cancer in western countries. Ovarian carcinoma is commonly associated with the accumulation of fluid that contains malignant cells in the peritoneal and pleural cavities. This article details the current knowledge regarding the diagnostic and biologic characteristics of ovarian carcinoma cells in effusions, and the genotypic and phenotypic differences between solid primary tumors and metastatic lesions. Finally, we present a new approach, by which the analysis of fresh frozen viable cells allows us to study in vivo the links between expression and activity of extracellular mediators, membrane receptors, intracellular signaling, and transcription factors, and their potential therapeutic and prognostic significance.

Original languageEnglish
Pages (from-to)729-754
Number of pages26
JournalClinics in Laboratory Medicine
Volume23
Issue number3
DOIs
StatePublished - Sep 2003

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