TY - JOUR
T1 - Effusion cytology in ovarian cancer
T2 - New molecular methods as aids to diagnosis and prognosis
AU - Davidson, Ben
AU - Risberg, Björn
AU - Reich, Reuven
AU - Berner, Aasmund
PY - 2003/9
Y1 - 2003/9
N2 - Carcinoma of the ovary is the leading cause of death from gynecologic cancer in western countries. Ovarian carcinoma is commonly associated with the accumulation of fluid that contains malignant cells in the peritoneal and pleural cavities. This article details the current knowledge regarding the diagnostic and biologic characteristics of ovarian carcinoma cells in effusions, and the genotypic and phenotypic differences between solid primary tumors and metastatic lesions. Finally, we present a new approach, by which the analysis of fresh frozen viable cells allows us to study in vivo the links between expression and activity of extracellular mediators, membrane receptors, intracellular signaling, and transcription factors, and their potential therapeutic and prognostic significance.
AB - Carcinoma of the ovary is the leading cause of death from gynecologic cancer in western countries. Ovarian carcinoma is commonly associated with the accumulation of fluid that contains malignant cells in the peritoneal and pleural cavities. This article details the current knowledge regarding the diagnostic and biologic characteristics of ovarian carcinoma cells in effusions, and the genotypic and phenotypic differences between solid primary tumors and metastatic lesions. Finally, we present a new approach, by which the analysis of fresh frozen viable cells allows us to study in vivo the links between expression and activity of extracellular mediators, membrane receptors, intracellular signaling, and transcription factors, and their potential therapeutic and prognostic significance.
UR - http://www.scopus.com/inward/record.url?scp=0141731370&partnerID=8YFLogxK
U2 - 10.1016/S0272-2712(03)00058-1
DO - 10.1016/S0272-2712(03)00058-1
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C2 - 14560537
AN - SCOPUS:0141731370
SN - 0272-2712
VL - 23
SP - 729
EP - 754
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
IS - 3
ER -