Eicosanoids, but not tachykinins, excite C-fiber endings in rat sciatic nerve-end neuromas

M. Devor*, D. M. White, E. J. Goetzl, J. D. Levine

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Normal nociceptors are sensitized by hyperalgesic mediators such as eicosanoids and tachykinins. The possibility that these mediators contribute to hyperalgesic pain associated with neural injury was investigated by examining their effects on the excitability of injured afferent nerve endings. In amounts that sensitize normal nociceptors and are hyperalgesic in normal skin, the eicosanoids prostaglandin I2 (PGI2), and 8(R),15(S)-dihydroxyicosatetraenoic acid (8(R),15(S)-diHETE) both excited some C-fibers in chronic neuromas of rat sciatic nerve. In contrast, the selective tachykinin-receptor agonists septide and senktide did not excite C-fibers. None of the mediators affected A-fibers. We conclude that PGI2 and 8(R),15(S)-diHETE may contribute to post-injury pain and hyperalgesia by an action on injured afferent endings.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalNeuroReport
Volume3
Issue number1
DOIs
StatePublished - Jan 1992

Keywords

  • Ectopic hyperexcitability
  • Eicosanoids
  • Nerve injury
  • Nerve pathophysiology
  • Neuroma
  • Pain
  • Tachykinins

Fingerprint

Dive into the research topics of 'Eicosanoids, but not tachykinins, excite C-fiber endings in rat sciatic nerve-end neuromas'. Together they form a unique fingerprint.

Cite this