Electrically Responsive, Nanopatterned Surfaces for Triggered Delivery of Biologically Active Molecules into Cells

Mo Yuan Shen, Sivan Yuran, Yaron Aviv, Hailemichael Ayalew, Chun Hao Luo, Yu Han Tsai, Meital Reches*, Hsiao Hua Yu, Roy Shenhar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Polyelectrolyte multilayers (PEMs) assembled layer-by-layer have emerged as functional polymer films that are both stable and capable of containing drug molecules for controlled release applications. Most of these applications concentrate on sustained release, where the concentration of the released molecules remains rather constant with time. However, high-efficiency delivery requires obtaining high local concentrations at the vicinity of the cells, which is achieved by triggered release. Here, we show that a nanopatterned PEM platform demonstrates superior properties with respect to drug retention and triggered delivery. A chemically modified block copolymer film was used as a template for the selective deposition of poly(ethylene imine) and a charged derivative of the electroactive poly(3,4-ethylenedioxythiophene) together with a drug molecule. This nanopatterned PEM shows the following advantages: (1) high drug loading; (2) enhanced retention of the bioactive molecule; (3) release triggered by an electrochemical stimulus; (4) high efficacy of drug delivery to cells adsorbed on the surface compared to the delivery efficacy of a similar concentration of drug to cells suspended in a solution.

Original languageAmerican English
Pages (from-to)1201-1208
Number of pages8
JournalACS applied materials & interfaces
Issue number1
StatePublished - 9 Jan 2019

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.


  • block copolymers
  • cell viability
  • drug releasing
  • nanopatterning
  • polyelectrolyte multilayers
  • tissue engineering


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