Electrochemical Triggered Dissolution of Hydroxyapatite/Doxorubicin Nanocarriers

Ori Geuli, Maya Miller, Avia Leader, Lijie He, Naomi Melamed-Book, Edit Y. Tshuva, Meital Reches, Daniel Mandler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The controlled release of drugs by an external stimulus is of pivotal interest and importance as a means of increasing administration efficacy. Accordingly, many responsive systems have been developed based on primarily pH, temperature, and light changes. Here, a novel electrochemical triggered release of a doxorubicin (Dox)-loaded hydroxyapatite (HAp) nanoparticle (NP) system is presented. Dox is loaded onto HAp NPs by producing a stable dispersion in DMSO. The Dox-HAp NPs are electrophoretically deposited on a stainless steel (S.S) surface. The adsorbed Dox-HAp NPs are released either by applying a moderate electrochemical potential pulse or upon scanning the potential. Two mechanisms were proposed. The first is that the positive potential induces the desorption of the Dox-HAp NPs. Alternatively, the positive potential could drive the oxidation of water and generation of protons, causing the dissolution of the Dox-HAp NPs. In situ characterization techniques, such as atomic force microscopy (AFM) and confocal microscopy, were used to gain insight on the release mechanism. All measurements allude to the electrochemically driven dissolution of the Dox-HAp NPs and release of the embedded drug. In vitro antitumor activity against both HT-29 and A2780 cancer cells revealed that the efficacy of the released Dox was not significantly affected by the electrochemical process. We believe that the electrochemically triggered release of NPs could be applied to many other responsive systems.

Original languageAmerican English
Pages (from-to)1956-1966
Number of pages11
JournalACS Applied Bio Materials
Volume2
Issue number5
DOIs
StatePublished - 20 May 2019

Bibliographical note

Publisher Copyright:
© 2019 American Chemical Society.

Keywords

  • doxorubicin
  • electroresponsive
  • hydroxyapatite
  • nanoparticles

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