Electrochemically Driven Hydroxyapatite Nanoparticles Coating of Medical Implants

Ori Geuli, Noah Metoki, Noam Eliaz*, Daniel Mandler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Calcium phosphates are of great interest for biomedical applications such as bone tissue engineering, bone fillers, drug and gene delivery, and orthopedic and dental implant coating. Here, the first electrochemically driven coating of medical implants using hydroxyapatite (HAp) nanoparticles (NPs) as building blocks is reported. This uncommon combination offers a simple, straightforward, and economic process with well controllable, pure, single-phase HAp. Crystalline, pure HAp NPs are formed by precipitation reaction. The HAp NPs are dispersed by either citrate or poly(acrylic acid) to form pH sensitive dispersion. Controllable and homogeneous coating of medical implants is accomplished by altering the pH on the surface upon applying either a constant potential or current. The process involves protonation of the carboxylic acid moieties, which causes the irreversible aggregation of the HAp NPs due to diminishing the repulsive forces between the particles. Deposition is further demonstrated on a commercial dental implant. Moreover, the adhesion of the coating satisfies FDA and international standard requirements. A porous interconnected network of bone-like HAp layer is formed during soaking in a simulated body fluid for 30 d and is similar to bone generation, and it therefore holds promise for further in vivo testing.

Original languageAmerican English
Pages (from-to)8003-8010
Number of pages8
JournalAdvanced Functional Materials
Volume26
Issue number44
DOIs
StatePublished - 22 Nov 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • hydroxyapatite
  • implants
  • nanoparticles
  • potential-induced deposition

Fingerprint

Dive into the research topics of 'Electrochemically Driven Hydroxyapatite Nanoparticles Coating of Medical Implants'. Together they form a unique fingerprint.

Cite this