Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide

Lijie He; Sujoy Sarkar; Alexandre Barras; Rabah Boukherroub; Sabine Szunerits; Daniel Mandler

doi:10.1039/c7cc00381a

Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide

Lijie He, Sujoy Sarkar, Alexandre Barras, Rabah Boukherroub, Sabine Szunerits^*, Daniel Mandler

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The electrochemically triggered release of doxorubicin (DOX) from flexible electrodes modified electrophoretically with reduced graphene oxide (rGO)-DOX is reported. The release is driven by a positive potential pulse that decreases the pH of the rGO-DOX surface locally, which is confirmed by scanning electrochemical microscopy (SECM) in situ. In vitro cell viability tests confirms that the delivery system meets therapeutic needs.

Original language	American English
Pages (from-to)	4022-4025
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	28
DOIs	https://doi.org/10.1039/c7cc00381a
State	Published - 2017

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© The Royal Society of Chemistry.

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10.1039/c7cc00381a

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abstract = "The electrochemically triggered release of doxorubicin (DOX) from flexible electrodes modified electrophoretically with reduced graphene oxide (rGO)-DOX is reported. The release is driven by a positive potential pulse that decreases the pH of the rGO-DOX surface locally, which is confirmed by scanning electrochemical microscopy (SECM) in situ. In vitro cell viability tests confirms that the delivery system meets therapeutic needs.",

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AU - He, Lijie

AU - Sarkar, Sujoy

AU - Barras, Alexandre

AU - Boukherroub, Rabah

AU - Szunerits, Sabine

AU - Mandler, Daniel

PY - 2017

Y1 - 2017

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AB - The electrochemically triggered release of doxorubicin (DOX) from flexible electrodes modified electrophoretically with reduced graphene oxide (rGO)-DOX is reported. The release is driven by a positive potential pulse that decreases the pH of the rGO-DOX surface locally, which is confirmed by scanning electrochemical microscopy (SECM) in situ. In vitro cell viability tests confirms that the delivery system meets therapeutic needs.

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Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide

Abstract

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