Electron microscopic studies on assembly of herpes simplex virus upon removal of hydroxyurea block

A. Friedmann, J. E. Coward, H. S. Rosenkranz, C. Morgan

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The release of hydroxyurea treated, herpes simplex virus infected cells from the drug induced block resulted in the prompt assembly of infectious virus. Electron microscope observations at sequential intervals following removal of the drug revealed considerable synchrony of replication. This synchrony permitted stages in the complex process of core assembly to be examined in detail. The data suggest that after partial or complete assembly the nucleoprotein enters the differentiated capsid to become enfolded.

Original languageEnglish
Pages (from-to)171-181
Number of pages11
JournalJournal of General Virology
Volume26
Issue number2
DOIs
StatePublished - 1975
Externally publishedYes

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