Electrooxidation of New Synthetic Cannabinoids: Voltammetric Determination of Drugs in Seized Street Samples and Artificial Saliva

Marina Dronova, Evgeny Smolianitski, Ovadia Lev*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The electrochemical sensing of new psychoactive substances, synthetic cannabinoids (SCs), commonly marketed under the trade name "Spice" is explored for the first time. The electrooxidative transformations of 11 new indole and indazole SCs which are currently the predominant illicit smoking mixtures on the drug market is performed using cyclic and differential pulse voltammetry with various commercially available electrodes (Pt, GC, Bdd). It is found that SCs exhibit voltammetric responses that can be used for their detection in smoking mixtures and artificial saliva with limits of detection in the nanomolar range. The indole-based SCs exhibited an anodic peak at ∼1.5 V (vs Ag/Ag+) and ∼1.2 V (vs Ag/AgCl) in acetonitrile and artificial saliva, respectively, and the indazoles exhibited corresponding peaks at ∼1.7 V and ∼1.5 V. The voltammetric procedure was evaluated by prescreening of SCs in 12 confiscated street samples that were also independently analyzed by GC-MS and LC-MS techniques. A good agreement between the three analytical protocols was found. Voltammetry provides a tool for the prescreening of synthetic cannabinoid derivatives in seized materials and biological samples.

Original languageAmerican English
Pages (from-to)4487-4494
Number of pages8
JournalAnalytical Chemistry
Volume88
Issue number8
DOIs
StatePublished - 3 May 2016

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

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