Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals: En route to tertiary α-fluorinated carbonyl derivatives

Jian Qiang Huang; Zackaria Nairoukh; Ilan Marek

doi:10.1039/c8ob00067k

Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals: En route to tertiary α-fluorinated carbonyl derivatives

Jian Qiang Huang, Zackaria Nairoukh, Ilan Marek^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

Original language	English
Pages (from-to)	1079-1082
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	16
Issue number	7
DOIs	https://doi.org/10.1039/c8ob00067k
State	Published - 2018
Externally published	Yes

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© The Royal Society of Chemistry 2018.

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abstract = "A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.",

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AU - Marek, Ilan

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Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals: En route to tertiary α-fluorinated carbonyl derivatives

Abstract

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