Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals: En route to tertiary α-fluorinated carbonyl derivatives

Jian Qiang Huang, Zackaria Nairoukh, Ilan Marek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

Original languageAmerican English
Pages (from-to)1079-1082
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume16
Issue number7
DOIs
StatePublished - 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2018.

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