We reported herein a practical approach to acyclic tertiary α-hydroxy carbonyl compounds in only two chemical steps from alkynes with excellent diastereoselectivity through the oxidation of stereodefined polysubstituted silyl ketone aminals. The products could be smoothly converted to synthetically useful enantiomerically enriched 1,2-diol derivatives.
Bibliographical noteFunding Information:
This research was supported by a grant from the European Research Council under the Seventh Framework Program of the European Community (ERC Grant Agreement 338912). I. M. is holder of the Sir Michael and Lady Sobell Academic Chair.
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- Silylketone aminals
- Synthetic methods
- α-Hydroxy carbonyls