Electrophysiological properties of guinea pig septal neurons in vitro

J. López-Barneo*, G. Alvarez de Toledo, Y. Yarom

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The electrophysiological properties of septal neurons have been examined in vitro in guinea pig brain slices. These cells display different firing modes when stimulated by transmembrane current pulses depending on the amplitude of the depolarization. With small pulses septal neurons fire repetitive Na spikes but on larger depolarizations they respond with a single full-Na action potential which is followed by a number of spikes of smaller amplitude. A further increase in the amplitude of the pulse evokes powerful Ca spikes possibly generated in the dendrites. These Ca spikes appear with larger amplitude in presumptive intradendritic recordings. In many cells stimulation of the fimbria evoked postsynaptic responses consisting of either a depolarization, a hyperpolarization or a depolarization-hyperpolarization sequence.

Original languageEnglish
Pages (from-to)358-362
Number of pages5
JournalBrain Research
Volume347
Issue number2
DOIs
StatePublished - 18 Nov 1985

Keywords

  • brain slice
  • calcium conductance
  • dendritic spike
  • intracellular recording
  • intradendritic recording
  • septal neuron

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