Electrophysiological studies in American Quarter horses with neuroaxonal dystrophy

Carrie J. Finno; Monica Aleman; Ron Ofri; Steven R. Hollingsworth; John E. Madigan; Laramie Winfield; Danika L. Bannasch

doi:10.1111/j.1463-5224.2012.00997.x

Electrophysiological studies in American Quarter horses with neuroaxonal dystrophy

Carrie J. Finno^*, Monica Aleman, Ron Ofri, Steven R. Hollingsworth, John E. Madigan, Laramie Winfield, Danika L. Bannasch

^*Corresponding author for this work

The Koret School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Objective: Neuroaxonal dystrophy (NAD) is a disease characterized by the sudden onset of neurologic signs in horses ranging from 4 to 36months of age. Equine degenerative myeloencephalopathy (EDM), a disease that has been associated with low vitamin E concentrations, is considered a more advanced form of NAD. The objective of this report is to describe the electrophysiological features of NAD/EDM in American Quarter horses (QHs). Horses: Six NAD/EDM-affected QHs and six unaffected QHs were evaluated by ophthalmic examination and electroretinography. Five of the NAD/EDM-affected QH and five unaffected QHs were also evaluated by electroencephalography (EEG). Results: Ophthalmic examination, ERGs, and EEGs were unremarkable in NAD/EDM cases. Conclusions: Neuroaxonal dystrophy/EDM does not appear to cause clinical signs of ocular disease or functional ERG/EEG deficits in QHs.

Original language	American English
Pages (from-to)	3-7
Number of pages	5
Journal	Veterinary Ophthalmology
Volume	15
Issue number	SUPPL.2
DOIs	https://doi.org/10.1111/j.1463-5224.2012.00997.x
State	Published - Sep 2012

Keywords

Electroencephalogram
Electroretinogram
Equine degenerative myeloencephalopathy
Lipofuscin
Neuroaxonal dystrophy
Vitamin E

Access to Document

10.1111/j.1463-5224.2012.00997.x

Cite this

@article{549c9302bee9427ba4af9fcb472d873c,

title = "Electrophysiological studies in American Quarter horses with neuroaxonal dystrophy",

abstract = "Objective: Neuroaxonal dystrophy (NAD) is a disease characterized by the sudden onset of neurologic signs in horses ranging from 4 to 36months of age. Equine degenerative myeloencephalopathy (EDM), a disease that has been associated with low vitamin E concentrations, is considered a more advanced form of NAD. The objective of this report is to describe the electrophysiological features of NAD/EDM in American Quarter horses (QHs). Horses: Six NAD/EDM-affected QHs and six unaffected QHs were evaluated by ophthalmic examination and electroretinography. Five of the NAD/EDM-affected QH and five unaffected QHs were also evaluated by electroencephalography (EEG). Results: Ophthalmic examination, ERGs, and EEGs were unremarkable in NAD/EDM cases. Conclusions: Neuroaxonal dystrophy/EDM does not appear to cause clinical signs of ocular disease or functional ERG/EEG deficits in QHs.",

keywords = "Electroencephalogram, Electroretinogram, Equine degenerative myeloencephalopathy, Lipofuscin, Neuroaxonal dystrophy, Vitamin E",

author = "Finno, {Carrie J.} and Monica Aleman and Ron Ofri and Hollingsworth, {Steven R.} and Madigan, {John E.} and Laramie Winfield and Bannasch, {Danika L.}",

year = "2012",

month = sep,

doi = "10.1111/j.1463-5224.2012.00997.x",

language = "American English",

volume = "15",

pages = "3--7",

journal = "Veterinary Ophthalmology",

issn = "1463-5216",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "SUPPL.2",

}

TY - JOUR

T1 - Electrophysiological studies in American Quarter horses with neuroaxonal dystrophy

AU - Finno, Carrie J.

AU - Aleman, Monica

AU - Ofri, Ron

AU - Hollingsworth, Steven R.

AU - Madigan, John E.

AU - Winfield, Laramie

AU - Bannasch, Danika L.

PY - 2012/9

Y1 - 2012/9

N2 - Objective: Neuroaxonal dystrophy (NAD) is a disease characterized by the sudden onset of neurologic signs in horses ranging from 4 to 36months of age. Equine degenerative myeloencephalopathy (EDM), a disease that has been associated with low vitamin E concentrations, is considered a more advanced form of NAD. The objective of this report is to describe the electrophysiological features of NAD/EDM in American Quarter horses (QHs). Horses: Six NAD/EDM-affected QHs and six unaffected QHs were evaluated by ophthalmic examination and electroretinography. Five of the NAD/EDM-affected QH and five unaffected QHs were also evaluated by electroencephalography (EEG). Results: Ophthalmic examination, ERGs, and EEGs were unremarkable in NAD/EDM cases. Conclusions: Neuroaxonal dystrophy/EDM does not appear to cause clinical signs of ocular disease or functional ERG/EEG deficits in QHs.

AB - Objective: Neuroaxonal dystrophy (NAD) is a disease characterized by the sudden onset of neurologic signs in horses ranging from 4 to 36months of age. Equine degenerative myeloencephalopathy (EDM), a disease that has been associated with low vitamin E concentrations, is considered a more advanced form of NAD. The objective of this report is to describe the electrophysiological features of NAD/EDM in American Quarter horses (QHs). Horses: Six NAD/EDM-affected QHs and six unaffected QHs were evaluated by ophthalmic examination and electroretinography. Five of the NAD/EDM-affected QH and five unaffected QHs were also evaluated by electroencephalography (EEG). Results: Ophthalmic examination, ERGs, and EEGs were unremarkable in NAD/EDM cases. Conclusions: Neuroaxonal dystrophy/EDM does not appear to cause clinical signs of ocular disease or functional ERG/EEG deficits in QHs.

KW - Electroencephalogram

KW - Electroretinogram

KW - Equine degenerative myeloencephalopathy

KW - Lipofuscin

KW - Neuroaxonal dystrophy

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=84865707221&partnerID=8YFLogxK

U2 - 10.1111/j.1463-5224.2012.00997.x

DO - 10.1111/j.1463-5224.2012.00997.x

M3 - Article

C2 - 22432889

AN - SCOPUS:84865707221

SN - 1463-5216

VL - 15

SP - 3

EP - 7

JO - Veterinary Ophthalmology

JF - Veterinary Ophthalmology

IS - SUPPL.2

ER -

Electrophysiological studies in American Quarter horses with neuroaxonal dystrophy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this