Elementary arithmetic operations by enzymes: A model for metabolic pathway based computing

Ronan Baron; Oleg Lioubashevski; Eugenii Katz; Tamara Niazov; Itamar Willner

doi:10.1002/anie.200503314

Elementary arithmetic operations by enzymes: A model for metabolic pathway based computing

Ronan Baron^*
, Oleg Lioubashevski
, Eugenii Katz
, Tamara Niazov
, Itamar Willner

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

194 Scopus citations

Abstract

(Figure Presented) Physio-logical: A system of four enzymes, horseradish peroxidase, glucose dehydrogenase, glucose oxidase, and catalase, operate in parallel in the presence of NADH and NAD⁺ to yield AND and XOR gates (see picture). Glucose and H₂O₂ act as the inputs, and the absorbance that follows the production of gluconic acid or NADH provide the outputs of the AND and XOR gates, respectively.

Original language	English
Pages (from-to)	1572-1576
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	10
DOIs	https://doi.org/10.1002/anie.200503314
State	Published - 27 Feb 2006

Keywords

Enzymes
Logic gates
Metabolism
Redox chemistry

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10.1002/anie.200503314

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abstract = "(Figure Presented) Physio-logical: A system of four enzymes, horseradish peroxidase, glucose dehydrogenase, glucose oxidase, and catalase, operate in parallel in the presence of NADH and NAD+ to yield AND and XOR gates (see picture). Glucose and H2O2 act as the inputs, and the absorbance that follows the production of gluconic acid or NADH provide the outputs of the AND and XOR gates, respectively.",

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AU - Katz, Eugenii

AU - Niazov, Tamara

AU - Willner, Itamar

PY - 2006/2/27

Y1 - 2006/2/27

N2 - (Figure Presented) Physio-logical: A system of four enzymes, horseradish peroxidase, glucose dehydrogenase, glucose oxidase, and catalase, operate in parallel in the presence of NADH and NAD+ to yield AND and XOR gates (see picture). Glucose and H2O2 act as the inputs, and the absorbance that follows the production of gluconic acid or NADH provide the outputs of the AND and XOR gates, respectively.

AB - (Figure Presented) Physio-logical: A system of four enzymes, horseradish peroxidase, glucose dehydrogenase, glucose oxidase, and catalase, operate in parallel in the presence of NADH and NAD+ to yield AND and XOR gates (see picture). Glucose and H2O2 act as the inputs, and the absorbance that follows the production of gluconic acid or NADH provide the outputs of the AND and XOR gates, respectively.

KW - Enzymes

KW - Logic gates

KW - Metabolism

KW - Redox chemistry

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IS - 10

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Elementary arithmetic operations by enzymes: A model for metabolic pathway based computing

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Keywords

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