Elevated salivary potassium in paediatric CKD patients, a novel excretion pathway

Esti Davidovich; Miriam Davidovits; Benny Peretz; Joseph Shapira; Doron J. Aframian

doi:10.1093/ndt/gfq587

Elevated salivary potassium in paediatric CKD patients, a novel excretion pathway

Esti Davidovich, Miriam Davidovits, Benny Peretz, Joseph Shapira, Doron J. Aframian

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background. Hyperkalaemia is one of the complications of chronic renal failure. Gastrointestinal excretion and cellular uptake are two adaptive mechanisms for extra-renal potassium (K) disposal in these patients. The salivary glands' secretion system can actively excrete K into the oral cavity.Methods. We examined salivary K levels in four groups of paediatric chronic kidney disease (CKD) patients: 25 pre-dialytic (PreD) patients, 18 patients on maintenance dialysis (D), and 31 transplanted patients with a functioning graft (T), compared with 32 healthy children (C).Results. Salivary K levels were significantly higher in the D and PreD groups than the C group (P = 0.03 and P = 0.0004, respectively). Interestingly, a significant negative correlation was found between glomerular filtration rate and salivary K in PreD and T patients.Conclusions. We suggest an extension of the gastrointestinal adaptive K pathway via salivary gland secretion in patients suffering from hyperkalaemia.

Original language	English
Pages (from-to)	1541-1546
Number of pages	6
Journal	Nephrology Dialysis Transplantation
Volume	26
Issue number	5
DOIs	https://doi.org/10.1093/ndt/gfq587
State	Published - May 2011

Keywords

CKD
excretion
potassium
saliva
salivary glands

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Background. Hyperkalaemia is one of the complications of chronic renal failure. Gastrointestinal excretion and cellular uptake are two adaptive mechanisms for extra-renal potassium (K) disposal in these patients. The salivary glands' secretion system can actively excrete K into the oral cavity.Methods. We examined salivary K levels in four groups of paediatric chronic kidney disease (CKD) patients: 25 pre-dialytic (PreD) patients, 18 patients on maintenance dialysis (D), and 31 transplanted patients with a functioning graft (T), compared with 32 healthy children (C).Results. Salivary K levels were significantly higher in the D and PreD groups than the C group (P = 0.03 and P = 0.0004, respectively). Interestingly, a significant negative correlation was found between glomerular filtration rate and salivary K in PreD and T patients.Conclusions. We suggest an extension of the gastrointestinal adaptive K pathway via salivary gland secretion in patients suffering from hyperkalaemia.",

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AU - Davidovich, Esti

AU - Davidovits, Miriam

AU - Peretz, Benny

AU - Shapira, Joseph

AU - Aframian, Doron J.

PY - 2011/5

Y1 - 2011/5

N2 - Background. Hyperkalaemia is one of the complications of chronic renal failure. Gastrointestinal excretion and cellular uptake are two adaptive mechanisms for extra-renal potassium (K) disposal in these patients. The salivary glands' secretion system can actively excrete K into the oral cavity.Methods. We examined salivary K levels in four groups of paediatric chronic kidney disease (CKD) patients: 25 pre-dialytic (PreD) patients, 18 patients on maintenance dialysis (D), and 31 transplanted patients with a functioning graft (T), compared with 32 healthy children (C).Results. Salivary K levels were significantly higher in the D and PreD groups than the C group (P = 0.03 and P = 0.0004, respectively). Interestingly, a significant negative correlation was found between glomerular filtration rate and salivary K in PreD and T patients.Conclusions. We suggest an extension of the gastrointestinal adaptive K pathway via salivary gland secretion in patients suffering from hyperkalaemia.

AB - Background. Hyperkalaemia is one of the complications of chronic renal failure. Gastrointestinal excretion and cellular uptake are two adaptive mechanisms for extra-renal potassium (K) disposal in these patients. The salivary glands' secretion system can actively excrete K into the oral cavity.Methods. We examined salivary K levels in four groups of paediatric chronic kidney disease (CKD) patients: 25 pre-dialytic (PreD) patients, 18 patients on maintenance dialysis (D), and 31 transplanted patients with a functioning graft (T), compared with 32 healthy children (C).Results. Salivary K levels were significantly higher in the D and PreD groups than the C group (P = 0.03 and P = 0.0004, respectively). Interestingly, a significant negative correlation was found between glomerular filtration rate and salivary K in PreD and T patients.Conclusions. We suggest an extension of the gastrointestinal adaptive K pathway via salivary gland secretion in patients suffering from hyperkalaemia.

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KW - excretion

KW - potassium

KW - saliva

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Elevated salivary potassium in paediatric CKD patients, a novel excretion pathway

Abstract

Keywords

UN SDGs

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