Elevated salivary uric acid levels among adolescents with eating disorders

Ruth Giesser, Tanya Goltser-Dubner, Dalya Pevzner, Amit Shalev, Ranin Masarwa, Laura Canetti, Ayelet Meltzer, Nidal Qutna, Roi Ratson, Ela Kianski, Shikma Keller, Esti Galili-Weisstub, Ronen Segman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: Uric acid (UA) is increasingly recognized as having important physiological roles and associated with several peripheral and central pathophysiological outcomes, and might play a role in eating disorders (ED) pathogenesis. We investigated whether UA levels are altered among adolescents with ED. Methods: Morning salivary UA concentrations were compared between adolescents referred to treatment at the Herman Dana Center receiving a DSM-V diagnosis of an ED and matched healthy controls. Results: Salivary UA was significantly elevated among ED compared with control values (ED mean 3.9 ± 1.2 mg/dl, control mean 2.9 ± 1.9 mg/dl, t = − 3.13 df = 81, p = 0.003). Discussion: Salivary UA is elevated among adolescents with ED. Further studies are required to replicate and extend this finding and evaluate its generalizability as a state or trait marker as regards ED subtypes, other body fluids (plasma and cerebrospinal fluid), and recovery or premorbid stages, as well as its putative mechanistic relevance to ED. Level of Evidence: Level III, case-control analytic study.

Original languageAmerican English
Pages (from-to)1821-1825
Number of pages5
JournalEating and Weight Disorders
Volume25
Issue number6
DOIs
StatePublished - 1 Dec 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019, Springer Nature Switzerland AG.

Keywords

  • Adolescents
  • Anorexia nervosa
  • Bulimia nervosa
  • Eating disorder
  • Salivary uric acid

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