TY - JOUR
T1 - Elevated salivary uric acid levels among adolescents with eating disorders
AU - Giesser, Ruth
AU - Goltser-Dubner, Tanya
AU - Pevzner, Dalya
AU - Shalev, Amit
AU - Masarwa, Ranin
AU - Canetti, Laura
AU - Meltzer, Ayelet
AU - Qutna, Nidal
AU - Ratson, Roi
AU - Kianski, Ela
AU - Keller, Shikma
AU - Galili-Weisstub, Esti
AU - Segman, Ronen
N1 - Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Objective: Uric acid (UA) is increasingly recognized as having important physiological roles and associated with several peripheral and central pathophysiological outcomes, and might play a role in eating disorders (ED) pathogenesis. We investigated whether UA levels are altered among adolescents with ED. Methods: Morning salivary UA concentrations were compared between adolescents referred to treatment at the Herman Dana Center receiving a DSM-V diagnosis of an ED and matched healthy controls. Results: Salivary UA was significantly elevated among ED compared with control values (ED mean 3.9 ± 1.2 mg/dl, control mean 2.9 ± 1.9 mg/dl, t = − 3.13 df = 81, p = 0.003). Discussion: Salivary UA is elevated among adolescents with ED. Further studies are required to replicate and extend this finding and evaluate its generalizability as a state or trait marker as regards ED subtypes, other body fluids (plasma and cerebrospinal fluid), and recovery or premorbid stages, as well as its putative mechanistic relevance to ED. Level of Evidence: Level III, case-control analytic study.
AB - Objective: Uric acid (UA) is increasingly recognized as having important physiological roles and associated with several peripheral and central pathophysiological outcomes, and might play a role in eating disorders (ED) pathogenesis. We investigated whether UA levels are altered among adolescents with ED. Methods: Morning salivary UA concentrations were compared between adolescents referred to treatment at the Herman Dana Center receiving a DSM-V diagnosis of an ED and matched healthy controls. Results: Salivary UA was significantly elevated among ED compared with control values (ED mean 3.9 ± 1.2 mg/dl, control mean 2.9 ± 1.9 mg/dl, t = − 3.13 df = 81, p = 0.003). Discussion: Salivary UA is elevated among adolescents with ED. Further studies are required to replicate and extend this finding and evaluate its generalizability as a state or trait marker as regards ED subtypes, other body fluids (plasma and cerebrospinal fluid), and recovery or premorbid stages, as well as its putative mechanistic relevance to ED. Level of Evidence: Level III, case-control analytic study.
KW - Adolescents
KW - Anorexia nervosa
KW - Bulimia nervosa
KW - Eating disorder
KW - Salivary uric acid
UR - http://www.scopus.com/inward/record.url?scp=85074715547&partnerID=8YFLogxK
U2 - 10.1007/s40519-019-00799-1
DO - 10.1007/s40519-019-00799-1
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C2 - 31667778
AN - SCOPUS:85074715547
SN - 1124-4909
VL - 25
SP - 1821
EP - 1825
JO - Eating and Weight Disorders
JF - Eating and Weight Disorders
IS - 6
ER -