Elg1, a central player in genome stability

Inbal Gazy, Batia Liefshitz, Oren Parnas, Martin Kupiec*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

ELG1 is a conserved gene uncovered in a number of genetic screens in yeast aimed at identifying factors important in the maintenance of genome stability. Elg1's activity prevents gross chromosomal rearrangements, maintains proper telomere length regulation, helps repairing DNA damage created by a number of genotoxins and participates in sister chromatid cohesion. Elg1 is evolutionarily conserved, and its mammalian ortholog (also known as ATAD5) is embryonic lethal when lost in mice, acts as a tumor suppressor in mice and humans, exhibits physical interactions with components of the human Fanconi Anemia pathway and may be responsible for some of the phenotypes associated with neurofibromatosis. In this review, we summarize the information available on Elg1-related activities in yeast and mammals, and present models to explain how the different phenotypes observed in the absence of Elg1 activity are related.

Original languageAmerican English
Pages (from-to)267-279
Number of pages13
JournalMutation Research - Reviews in Mutation Research
Volume763
DOIs
StatePublished - 1 Jan 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V.

Keywords

  • Chromatin
  • DNA repair
  • DNA replication
  • Genome stability
  • Sister chromatid cohesion
  • Telomere length regulation

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