Elg1, a central player in genome stability

Inbal Gazy; Batia Liefshitz; Oren Parnas; Martin Kupiec

doi:10.1016/j.mrrev.2014.11.007

Elg1, a central player in genome stability

Inbal Gazy, Batia Liefshitz, Oren Parnas, Martin Kupiec^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

ELG1 is a conserved gene uncovered in a number of genetic screens in yeast aimed at identifying factors important in the maintenance of genome stability. Elg1's activity prevents gross chromosomal rearrangements, maintains proper telomere length regulation, helps repairing DNA damage created by a number of genotoxins and participates in sister chromatid cohesion. Elg1 is evolutionarily conserved, and its mammalian ortholog (also known as ATAD5) is embryonic lethal when lost in mice, acts as a tumor suppressor in mice and humans, exhibits physical interactions with components of the human Fanconi Anemia pathway and may be responsible for some of the phenotypes associated with neurofibromatosis. In this review, we summarize the information available on Elg1-related activities in yeast and mammals, and present models to explain how the different phenotypes observed in the absence of Elg1 activity are related.

Original language	English
Pages (from-to)	267-279
Number of pages	13
Journal	Mutation Research - Reviews in Mutation Research
Volume	763
DOIs	https://doi.org/10.1016/j.mrrev.2014.11.007
State	Published - 1 Jan 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V.

Keywords

Chromatin
DNA repair
DNA replication
Genome stability
Sister chromatid cohesion
Telomere length regulation

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10.1016/j.mrrev.2014.11.007

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abstract = "ELG1 is a conserved gene uncovered in a number of genetic screens in yeast aimed at identifying factors important in the maintenance of genome stability. Elg1's activity prevents gross chromosomal rearrangements, maintains proper telomere length regulation, helps repairing DNA damage created by a number of genotoxins and participates in sister chromatid cohesion. Elg1 is evolutionarily conserved, and its mammalian ortholog (also known as ATAD5) is embryonic lethal when lost in mice, acts as a tumor suppressor in mice and humans, exhibits physical interactions with components of the human Fanconi Anemia pathway and may be responsible for some of the phenotypes associated with neurofibromatosis. In this review, we summarize the information available on Elg1-related activities in yeast and mammals, and present models to explain how the different phenotypes observed in the absence of Elg1 activity are related.",

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Elg1, a central player in genome stability

Abstract

Bibliographical note

Keywords

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