Enantiomer resolution of nefopam hydrochloride, a novel analgesic: a study by liquid chromatography and circular dichroism spectroscopy

Roland Isaksson; Jan Sandström; Michal Eliaz; Zehorith Israely; Israel Agranat

doi:10.1111/j.2042-7158.1988.tb05148.x

Enantiomer resolution of nefopam hydrochloride, a novel analgesic: a study by liquid chromatography and circular dichroism spectroscopy

Roland Isaksson
, Jan Sandström
, Michal Eliaz
, Zehorith Israely
, Israel Agranat^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Abstract— Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low‐pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported. 1988 Royal Pharmaceutical Society of Great Britain

Original language	English
Pages (from-to)	48-50
Number of pages	3
Journal	Journal of Pharmacy and Pharmacology
Volume	40
Issue number	1
DOIs	https://doi.org/10.1111/j.2042-7158.1988.tb05148.x
State	Published - Jan 1988

Access to Document

10.1111/j.2042-7158.1988.tb05148.x

Cite this

@article{c55d42af80aa4b9ebd8dce9c417690e8,

title = "Enantiomer resolution of nefopam hydrochloride, a novel analgesic: a study by liquid chromatography and circular dichroism spectroscopy",

abstract = "Abstract— Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low‐pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported. 1988 Royal Pharmaceutical Society of Great Britain",

author = "Roland Isaksson and Jan Sandstr{\"o}m and Michal Eliaz and Zehorith Israely and Israel Agranat",

year = "1988",

month = jan,

doi = "10.1111/j.2042-7158.1988.tb05148.x",

language = "אנגלית",

volume = "40",

pages = "48--50",

journal = "Journal of Pharmacy and Pharmacology",

issn = "0022-3573",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Enantiomer resolution of nefopam hydrochloride, a novel analgesic

T2 - a study by liquid chromatography and circular dichroism spectroscopy

AU - Isaksson, Roland

AU - Sandström, Jan

AU - Eliaz, Michal

AU - Israely, Zehorith

AU - Agranat, Israel

PY - 1988/1

Y1 - 1988/1

N2 - Abstract— Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low‐pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported. 1988 Royal Pharmaceutical Society of Great Britain

AB - Abstract— Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low‐pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported. 1988 Royal Pharmaceutical Society of Great Britain

UR - https://www.scopus.com/pages/publications/0023839165

U2 - 10.1111/j.2042-7158.1988.tb05148.x

DO - 10.1111/j.2042-7158.1988.tb05148.x

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 2896773

AN - SCOPUS:0023839165

SN - 0022-3573

VL - 40

SP - 48

EP - 50

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

IS - 1

ER -

Enantiomer resolution of nefopam hydrochloride, a novel analgesic: a study by liquid chromatography and circular dichroism spectroscopy

Abstract

Access to Document

Other files and links

Fingerprint

Cite this