Enantiomerically enriched cyclopropene derivatives: Versatile building blocks in asymmetric synthesis

Ilan Marek*, Samah Simaan, Ahmad Masarwa

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

223 Scopus citations

Abstract

(Chemical Presented) Enantiomerically enriched cyclopropene derivatives, the smallest possible unsaturated carbocycles, are of great synthetic interest since they serve as versatile reactive building blocks. Their reactivity results from the relief of the ring strain in the small molecule. They can be transformed into a wide variety of complex chiral structures and a special emphasis will be directed towards the preparation of enantiomerically enriched methylene- and alkylidenecyclopropane derivatives. The ready availability of a wide range of these chiral entities now provides an excellent opportunity to discover new and unique transformations that can further enrich mainstream synthetic methodology.

Original languageAmerican English
Pages (from-to)7364-7376
Number of pages13
JournalAngewandte Chemie - International Edition
Volume46
Issue number39
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Carbometalation
  • Chirality
  • Cyclopropenes
  • Small ring systems
  • Strained molecules

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