TY - JOUR
T1 - Endogenous and synthetic cannabinoids
T2 - Recent advances
AU - Shohami, Esther
AU - Weidenfeld, Joseph
AU - Ovadia, Haim
AU - Vogel, Zvi
AU - Hanuš, Lumir
AU - Fride, Ester
AU - Breuer, Aviva
AU - Ben-Shabat, Shimon
AU - Sheskin, Tzviel
AU - Mechoulam, Raphael
PY - 1996/12
Y1 - 1996/12
N2 - We have reviewed the effects of two endogenous cannabinoid constituents, anandamide and 2-Ara-G1, and of two synthetic cannabinoids, HU-211 and HU- 210. Anandamide partly parallels THC in most CNS activities; the lack of published data prevents comparison of 2-Ara-G1 with THC. Anandamide probably serves as a mediator in motor functions, in memory and, judging from the effects of THC in humans on mood and cognition, in emotions. 2-Ara-G1 probably plays a role in the immune system. HU-210, which is one of the most potent cannabinoids prepared so far as evidenced by observations on sedation, catalepsy and hypothermia, will presumably continue to serve as a potent tool for cannabinoid investigations. HU-211 which is not cannabimimetic, but is an NMDA antagonist, may become a drug used in neuroprotection and possibly in medical conditions associated with high levels of glutamate, tumor necrosis factor, and/or with impaired function of the BBB.
AB - We have reviewed the effects of two endogenous cannabinoid constituents, anandamide and 2-Ara-G1, and of two synthetic cannabinoids, HU-211 and HU- 210. Anandamide partly parallels THC in most CNS activities; the lack of published data prevents comparison of 2-Ara-G1 with THC. Anandamide probably serves as a mediator in motor functions, in memory and, judging from the effects of THC in humans on mood and cognition, in emotions. 2-Ara-G1 probably plays a role in the immune system. HU-210, which is one of the most potent cannabinoids prepared so far as evidenced by observations on sedation, catalepsy and hypothermia, will presumably continue to serve as a potent tool for cannabinoid investigations. HU-211 which is not cannabimimetic, but is an NMDA antagonist, may become a drug used in neuroprotection and possibly in medical conditions associated with high levels of glutamate, tumor necrosis factor, and/or with impaired function of the BBB.
KW - 2-Arachidonoyl-glycerol
KW - Anandamide
KW - Cannabinoid receptors
KW - Head trauma
KW - HU- 210
KW - HU-211-δ-Tetrahydrocannabinol
UR - http://www.scopus.com/inward/record.url?scp=12644253801&partnerID=8YFLogxK
U2 - 10.1111/j.1527-3458.1996.tb00310.x
DO - 10.1111/j.1527-3458.1996.tb00310.x
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AN - SCOPUS:12644253801
SN - 1080-563X
VL - 2
SP - 429
EP - 451
JO - CNS Drug Reviews
JF - CNS Drug Reviews
IS - 4
ER -