Endogenous ‘ouabain like’ activity in rat brain

David Lichtstein; Sarah Samuelov

doi:10.1016/0006-291X(80)91346-7

Endogenous ‘ouabain like’ activity in rat brain

David Lichtstein^*, Sarah Samuelov

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

The presence of an endogenous ‘ouabain like’ compound in rat brain is demonstrated based on the ability of acid acetone extracts of brain to inhibit [³H] ouabain binding and Na⁺,K⁺-ATPase activity. Partial purification of the inhibitory activity was achieved by methanol and trichloroacetic acid fractionations followed by Sephadex G-25 chromatography. The results are discussed with relation to the possible role of the endogenous ‘ouabain like’ compound in the regulation of the Na⁺,K⁺ pump activity.

Original language	English
Pages (from-to)	1518-1523
Number of pages	6
Journal	Topics in Catalysis
Volume	96
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(80)91346-7
State	Published - 1980

Access to Document

10.1016/0006-291X(80)91346-7

Cite this

@article{58db81fc929542d4a8c49d502d83cd22,

title = "Endogenous {\textquoteleft}ouabain like{\textquoteright} activity in rat brain",

abstract = "The presence of an endogenous {\textquoteleft}ouabain like{\textquoteright} compound in rat brain is demonstrated based on the ability of acid acetone extracts of brain to inhibit [3H] ouabain binding and Na+,K+-ATPase activity. Partial purification of the inhibitory activity was achieved by methanol and trichloroacetic acid fractionations followed by Sephadex G-25 chromatography. The results are discussed with relation to the possible role of the endogenous {\textquoteleft}ouabain like{\textquoteright} compound in the regulation of the Na+,K+ pump activity.",

author = "David Lichtstein and Sarah Samuelov",

year = "1980",

doi = "10.1016/0006-291X(80)91346-7",

language = "אנגלית",

volume = "96",

pages = "1518--1523",

journal = "Topics in Catalysis",

number = "4",

}

TY - JOUR

T1 - Endogenous ‘ouabain like’ activity in rat brain

AU - Lichtstein, David

AU - Samuelov, Sarah

PY - 1980

Y1 - 1980

N2 - The presence of an endogenous ‘ouabain like’ compound in rat brain is demonstrated based on the ability of acid acetone extracts of brain to inhibit [3H] ouabain binding and Na+,K+-ATPase activity. Partial purification of the inhibitory activity was achieved by methanol and trichloroacetic acid fractionations followed by Sephadex G-25 chromatography. The results are discussed with relation to the possible role of the endogenous ‘ouabain like’ compound in the regulation of the Na+,K+ pump activity.

AB - The presence of an endogenous ‘ouabain like’ compound in rat brain is demonstrated based on the ability of acid acetone extracts of brain to inhibit [3H] ouabain binding and Na+,K+-ATPase activity. Partial purification of the inhibitory activity was achieved by methanol and trichloroacetic acid fractionations followed by Sephadex G-25 chromatography. The results are discussed with relation to the possible role of the endogenous ‘ouabain like’ compound in the regulation of the Na+,K+ pump activity.

UR - http://www.scopus.com/inward/record.url?scp=0019119750&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(80)91346-7

DO - 10.1016/0006-291X(80)91346-7

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 6255945

AN - SCOPUS:0019119750

VL - 96

SP - 1518

EP - 1523

JO - Topics in Catalysis

JF - Topics in Catalysis

IS - 4

ER -

Endogenous ‘ouabain like’ activity in rat brain

Abstract

Access to Document

Other files and links

Fingerprint

Cite this