Endogenous ‘ouabain like’ activity in rat brain

David Lichtstein; Sarah Samuelov

doi:10.1016/0006-291X(80)91346-7

Endogenous ‘ouabain like’ activity in rat brain

David Lichtstein^*, Sarah Samuelov

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

The presence of an endogenous ‘ouabain like’ compound in rat brain is demonstrated based on the ability of acid acetone extracts of brain to inhibit [³H] ouabain binding and Na⁺,K⁺-ATPase activity. Partial purification of the inhibitory activity was achieved by methanol and trichloroacetic acid fractionations followed by Sephadex G-25 chromatography. The results are discussed with relation to the possible role of the endogenous ‘ouabain like’ compound in the regulation of the Na⁺,K⁺ pump activity.

Original language	English
Pages (from-to)	1518-1523
Number of pages	6
Journal	Topics in Catalysis
Volume	96
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(80)91346-7
State	Published - 1980

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title = "Endogenous {\textquoteleft}ouabain like{\textquoteright} activity in rat brain",

abstract = "The presence of an endogenous {\textquoteleft}ouabain like{\textquoteright} compound in rat brain is demonstrated based on the ability of acid acetone extracts of brain to inhibit [3H] ouabain binding and Na+,K+-ATPase activity. Partial purification of the inhibitory activity was achieved by methanol and trichloroacetic acid fractionations followed by Sephadex G-25 chromatography. The results are discussed with relation to the possible role of the endogenous {\textquoteleft}ouabain like{\textquoteright} compound in the regulation of the Na+,K+ pump activity.",

author = "David Lichtstein and Sarah Samuelov",

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journal = "Topics in Catalysis",

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AU - Lichtstein, David

AU - Samuelov, Sarah

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N2 - The presence of an endogenous ‘ouabain like’ compound in rat brain is demonstrated based on the ability of acid acetone extracts of brain to inhibit [3H] ouabain binding and Na+,K+-ATPase activity. Partial purification of the inhibitory activity was achieved by methanol and trichloroacetic acid fractionations followed by Sephadex G-25 chromatography. The results are discussed with relation to the possible role of the endogenous ‘ouabain like’ compound in the regulation of the Na+,K+ pump activity.

AB - The presence of an endogenous ‘ouabain like’ compound in rat brain is demonstrated based on the ability of acid acetone extracts of brain to inhibit [3H] ouabain binding and Na+,K+-ATPase activity. Partial purification of the inhibitory activity was achieved by methanol and trichloroacetic acid fractionations followed by Sephadex G-25 chromatography. The results are discussed with relation to the possible role of the endogenous ‘ouabain like’ compound in the regulation of the Na+,K+ pump activity.

UR - https://www.scopus.com/pages/publications/0019119750

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VL - 96

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JO - Topics in Catalysis

JF - Topics in Catalysis

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Endogenous ‘ouabain like’ activity in rat brain

Abstract

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