Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-α and IL-6 secretion

A. Reichenberg; T. Kraus; M. Haack; A. Schuld; T. Pollmächer; R. Yirmiya

doi:10.1016/S0306-4530(01)00101-9

Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-α and IL-6 secretion

A. Reichenberg^*
, T. Kraus
, M. Haack
, A. Schuld
, T. Pollmächer
, R. Yirmiya

^*Corresponding author for this work

Department of Psychology

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

This study examined the effects of endotoxin administration on food and water consumption in humans, and the associations between these changes and endotoxin-induced secretion of cytokines, cortisol, and fever. Twenty healthy male volunteers received an i.v. injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in two experimental sessions. Blood samples were collected hourly, and rectal temperature was monitored continuously. Food consumption was significantly reduced at 0-4 h and significantly elevated at 4-5 h after the endotoxin injection. Endotoxin administration had no significant effect on water consumption. Endotoxin-induced secretion of TNF-α and IL-6 was positively associated with the decrease in food consumption (r=0.61 and 0.68), and negatively associated with the rebound increase in food consumption (r=-0.53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF-α and IL-6 are involved in endotoxin-induced anorexia in humans.

Original language	English
Pages (from-to)	945-956
Number of pages	12
Journal	Psychoneuroendocrinology
Volume	27
Issue number	8
DOIs	https://doi.org/10.1016/S0306-4530(01)00101-9
State	Published - Nov 2002

Bibliographical note

Funding Information:
The authors would like to thank Dr Chris Galanos (Max-Planck Institute of Immunobiology, Freiburg) for kindly providing the endotoxin preparation used in this study. This research was supported by a Grant from the G.I.F., the German-Israeli Foundation for Scientific Research and Development. R.Y. is a member of the Eric Roland Center for Neurodegenerative Diseases of the Hebrew University of Jerusalem.

Keywords

Anorexia
Cytokines
Endotoxin
Food consumption

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10.1016/S0306-4530(01)00101-9

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title = "Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-α and IL-6 secretion",

abstract = "This study examined the effects of endotoxin administration on food and water consumption in humans, and the associations between these changes and endotoxin-induced secretion of cytokines, cortisol, and fever. Twenty healthy male volunteers received an i.v. injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in two experimental sessions. Blood samples were collected hourly, and rectal temperature was monitored continuously. Food consumption was significantly reduced at 0-4 h and significantly elevated at 4-5 h after the endotoxin injection. Endotoxin administration had no significant effect on water consumption. Endotoxin-induced secretion of TNF-α and IL-6 was positively associated with the decrease in food consumption (r=0.61 and 0.68), and negatively associated with the rebound increase in food consumption (r=-0.53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF-α and IL-6 are involved in endotoxin-induced anorexia in humans.",

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author = "A. Reichenberg and T. Kraus and M. Haack and A. Schuld and T. Pollm{\"a}cher and R. Yirmiya",

note = "Funding Information: The authors would like to thank Dr Chris Galanos (Max-Planck Institute of Immunobiology, Freiburg) for kindly providing the endotoxin preparation used in this study. This research was supported by a Grant from the G.I.F., the German-Israeli Foundation for Scientific Research and Development. R.Y. is a member of the Eric Roland Center for Neurodegenerative Diseases of the Hebrew University of Jerusalem.",

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AU - Reichenberg, A.

AU - Kraus, T.

AU - Haack, M.

AU - Schuld, A.

AU - Pollmächer, T.

AU - Yirmiya, R.

N1 - Funding Information: The authors would like to thank Dr Chris Galanos (Max-Planck Institute of Immunobiology, Freiburg) for kindly providing the endotoxin preparation used in this study. This research was supported by a Grant from the G.I.F., the German-Israeli Foundation for Scientific Research and Development. R.Y. is a member of the Eric Roland Center for Neurodegenerative Diseases of the Hebrew University of Jerusalem.

PY - 2002/11

Y1 - 2002/11

N2 - This study examined the effects of endotoxin administration on food and water consumption in humans, and the associations between these changes and endotoxin-induced secretion of cytokines, cortisol, and fever. Twenty healthy male volunteers received an i.v. injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in two experimental sessions. Blood samples were collected hourly, and rectal temperature was monitored continuously. Food consumption was significantly reduced at 0-4 h and significantly elevated at 4-5 h after the endotoxin injection. Endotoxin administration had no significant effect on water consumption. Endotoxin-induced secretion of TNF-α and IL-6 was positively associated with the decrease in food consumption (r=0.61 and 0.68), and negatively associated with the rebound increase in food consumption (r=-0.53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF-α and IL-6 are involved in endotoxin-induced anorexia in humans.

AB - This study examined the effects of endotoxin administration on food and water consumption in humans, and the associations between these changes and endotoxin-induced secretion of cytokines, cortisol, and fever. Twenty healthy male volunteers received an i.v. injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in two experimental sessions. Blood samples were collected hourly, and rectal temperature was monitored continuously. Food consumption was significantly reduced at 0-4 h and significantly elevated at 4-5 h after the endotoxin injection. Endotoxin administration had no significant effect on water consumption. Endotoxin-induced secretion of TNF-α and IL-6 was positively associated with the decrease in food consumption (r=0.61 and 0.68), and negatively associated with the rebound increase in food consumption (r=-0.53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF-α and IL-6 are involved in endotoxin-induced anorexia in humans.

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Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-α and IL-6 secretion

Abstract

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Keywords

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