Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons

Keyphrases

• Human Cholinesterase 100%
• Butyrylcholinesterase (BChE) 100%
• Cocaine 66%
• Cholinesterase 66%
• Heterologous Expression 33%
• Recombinant 33%
• Hydrolytic Enzymes 33%
• Tissue Expression 33%
• Acetylcholinesterase 33%
• Site-directed mutagenesis 33%
• Local Anesthetics 33%
• Acetylcholine 33%
• Nerve Conduction 33%
• Intercellular Communication 33%
• Anticholinesterase 33%
• Aggregation Behavior 33%
• Aspirin 33%
• Scavenger 33%
• Non-catalytic 33%
• Organophosphorus Insecticides 33%
• Carbamate Insecticides 33%
• Glycoalkaloids 33%
• Catalytic Role 33%
• Aggregate Variables 33%
• Surface Element 33%
• AChBP 33%
• Alternative mRNA Splicing 33%

Neuroscience

• Acetylcholine 100%
• Enzymes 100%
• Acetylcholinesterase 50%
• Protein Binding 50%
• Nerve Conduction 50%
• Alternative Splicing 50%
• Hydrolase 50%
• Anticholinesterases 50%
• Heterologous Expression 50%
• Site-Directed Mutagenesis 50%
• Aspirin 50%
• Carbamate Insecticide 50%
• Organophosphate Insecticide 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Acetylcholine 100%
• Enzymes 100%
• Acetylsalicylic Acid 50%
• Cholinesterase Inhibitor 50%
• Hydrolase 50%
• Acetylcholinesterase 50%
• Site-Directed Mutagenesis 50%
• Binding Protein 50%
• Organophosphate Insecticide 50%
• Carbamate Insecticide 50%
• Local Anesthetic Agent 50%
• Messenger RNA 50%