Engraftment and development of human T and B cells in mice after bone marrow transplantation

Ido Lubin; Yifat Faktorowich; Tsvee Lapidot; Yehudit Gan; Zelig Eshhar; Ephraim Gazit; Mia Levite; Yair Reisner

Engraftment and development of human T and B cells in mice after bone marrow transplantation

Ido Lubin, Yifat Faktorowich, Tsvee Lapidot, Yehudit Gan, Zelig Eshhar, Ephraim Gazit, Mia Levite, Yair Reisner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3⁺CD4⁺CD8⁺. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.

Original language	English
Pages (from-to)	427-431
Number of pages	5
Journal	Science
Volume	252
Issue number	5004
State	Published - 19 Apr 1991
Externally published	Yes

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abstract = "A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.",

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AU - Lubin, Ido

AU - Faktorowich, Yifat

AU - Lapidot, Tsvee

AU - Gan, Yehudit

AU - Eshhar, Zelig

AU - Gazit, Ephraim

AU - Levite, Mia

AU - Reisner, Yair

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AB - A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.

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Engraftment and development of human T and B cells in mice after bone marrow transplantation

Abstract

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