Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device

Micha E. Spira; Dotan Kamber; Ada Dormannl; Ariel Cohenl; Carmen Bartic; Gustaaf Borghs; Keren Shabthai; J. P.M.Langedijk Langedijk; Shlomo Yitzchaik; Josef Shappir

doi:10.1557/proc-1004-p02-05

Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device

Micha E. Spira, Dotan Kamber, Ada Dormannl, Ariel Cohenl, Carmen Bartic, Gustaaf Borghs, Keren Shabthai, J. P.M.Langedijk Langedijk, Shlomo Yitzchaik, Josef Shappir

Institute of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

One of the major problems in assembling efficient neuro-electronic hybrids systems is the low electrical coupling between the components. This is mainly due to the low resistance, extracellular cleft formed between the cell's plasma membrane and the substrate to which it adhere. This cleft shunts the current generated by the neuron, or the device and thus reduces the signal to noise ratio. To increase the clefts electrical resistance we fabricated gold micronails that protrude from the transistor gate surface. The micronails were functionalized by phagocytosis facilitating peptides. Cultured neurons readily engulf the functionalized micronails forming tight physical contact between the cells and the surface of the device.

Original language	English
Title of host publication	Materials Research Society Symposium Proceedings - Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures
Publisher	Materials Research Society
Pages	20-25
Number of pages	6
ISBN (Print)	9781605604381
DOIs	https://doi.org/10.1557/proc-1004-p02-05
State	Published - 2007
Event	Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures - 2007 MRS Spring Meeting - San Francisco, CA, United States Duration: 9 Apr 2007 → 13 Apr 2007

Publication series

Name	Materials Research Society Symposium Proceedings
Volume	1004
ISSN (Print)	0272-9172

Conference

Conference	Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures - 2007 MRS Spring Meeting
Country/Territory	United States
City	San Francisco, CA
Period	9/04/07 → 13/04/07

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Spira, M. E., Kamber, D., Dormannl, A., Cohenl, A., Bartic, C., Borghs, G., Shabthai, K., Langedijk, J. P. M. L., Yitzchaik, S., & Shappir, J. (2007). Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device. In Materials Research Society Symposium Proceedings - Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures (pp. 20-25). (Materials Research Society Symposium Proceedings; Vol. 1004). Materials Research Society. https://doi.org/10.1557/proc-1004-p02-05

Spira, Micha E. ; Kamber, Dotan ; Dormannl, Ada et al. / Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device. Materials Research Society Symposium Proceedings - Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures. Materials Research Society, 2007. pp. 20-25 (Materials Research Society Symposium Proceedings).

@inproceedings{016745c686c74dc4be3684af47f20249,

title = "Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device",

abstract = "One of the major problems in assembling efficient neuro-electronic hybrids systems is the low electrical coupling between the components. This is mainly due to the low resistance, extracellular cleft formed between the cell's plasma membrane and the substrate to which it adhere. This cleft shunts the current generated by the neuron, or the device and thus reduces the signal to noise ratio. To increase the clefts electrical resistance we fabricated gold micronails that protrude from the transistor gate surface. The micronails were functionalized by phagocytosis facilitating peptides. Cultured neurons readily engulf the functionalized micronails forming tight physical contact between the cells and the surface of the device.",

author = "Spira, {Micha E.} and Dotan Kamber and Ada Dormannl and Ariel Cohenl and Carmen Bartic and Gustaaf Borghs and Keren Shabthai and Langedijk, {J. P.M.Langedijk} and Shlomo Yitzchaik and Josef Shappir",

year = "2007",

doi = "10.1557/proc-1004-p02-05",

language = "אנגלית",

isbn = "9781605604381",

series = "Materials Research Society Symposium Proceedings",

publisher = "Materials Research Society",

pages = "20--25",

booktitle = "Materials Research Society Symposium Proceedings - Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures",

address = "ארצות הברית",

note = "Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures - 2007 MRS Spring Meeting ; Conference date: 09-04-2007 Through 13-04-2007",

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Spira, ME, Kamber, D, Dormannl, A, Cohenl, A, Bartic, C, Borghs, G, Shabthai, K, Langedijk, JPML, Yitzchaik, S & Shappir, J 2007, Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device. in Materials Research Society Symposium Proceedings - Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures. Materials Research Society Symposium Proceedings, vol. 1004, Materials Research Society, pp. 20-25, Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures - 2007 MRS Spring Meeting, San Francisco, CA, United States, 9/04/07. https://doi.org/10.1557/proc-1004-p02-05

Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device. / Spira, Micha E.; Kamber, Dotan; Dormannl, Ada et al.
Materials Research Society Symposium Proceedings - Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures. Materials Research Society, 2007. p. 20-25 (Materials Research Society Symposium Proceedings; Vol. 1004).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Spira, Micha E.

AU - Kamber, Dotan

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AU - Bartic, Carmen

AU - Borghs, Gustaaf

AU - Shabthai, Keren

AU - Langedijk, J. P.M.Langedijk

AU - Yitzchaik, Shlomo

AU - Shappir, Josef

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AB - One of the major problems in assembling efficient neuro-electronic hybrids systems is the low electrical coupling between the components. This is mainly due to the low resistance, extracellular cleft formed between the cell's plasma membrane and the substrate to which it adhere. This cleft shunts the current generated by the neuron, or the device and thus reduces the signal to noise ratio. To increase the clefts electrical resistance we fabricated gold micronails that protrude from the transistor gate surface. The micronails were functionalized by phagocytosis facilitating peptides. Cultured neurons readily engulf the functionalized micronails forming tight physical contact between the cells and the surface of the device.

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Spira ME, Kamber D, Dormannl A, Cohenl A, Bartic C, Borghs G et al. Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device. In Materials Research Society Symposium Proceedings - Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures. Materials Research Society. 2007. p. 20-25. (Materials Research Society Symposium Proceedings). doi: 10.1557/proc-1004-p02-05

Engulfment of protruding micro-nails fabricated on chip surface by cultured neurons improve their adhesion to the electronic device

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