Enhanced adherence of β-thalassaemic erythrocytes to endothelial cells

T. Hovav, A. Goldfarb, G. Artmann, S. Yedgar*, G. Barshtein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

The adherence of red blood cells (RBC) to endothelial cells (EC), shown to correlate with microvascular occlusion in sickle cell disease and malaria, is considered a major contributor to microcirculatory disorders. In the present study the adherence to EC was markedly enhanced with RBC from β- thalassaemia major (TM) patients, and even more so with RBC from β- thalassaemia intermedia (TI) patients (10-fold and 25-fold higher than normal, respectively). It is proposed that enhanced RBC/EC adherence may contribute to the microcirculatory disorders observed in thalassaemia, especially in TI patients who are particularly known to suffer from leg ulcers.

Original languageAmerican English
Pages (from-to)178-181
Number of pages4
JournalBritish Journal of Haematology
Volume106
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Adhesion
  • Endothelial cells
  • Red blood cells
  • β-thalassaemia intermedia
  • β-thalassaemia major

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