TY - JOUR
T1 - Enhanced adherence of β-thalassaemic erythrocytes to endothelial cells
AU - Hovav, T.
AU - Goldfarb, A.
AU - Artmann, G.
AU - Yedgar, S.
AU - Barshtein, G.
PY - 1999
Y1 - 1999
N2 - The adherence of red blood cells (RBC) to endothelial cells (EC), shown to correlate with microvascular occlusion in sickle cell disease and malaria, is considered a major contributor to microcirculatory disorders. In the present study the adherence to EC was markedly enhanced with RBC from β- thalassaemia major (TM) patients, and even more so with RBC from β- thalassaemia intermedia (TI) patients (10-fold and 25-fold higher than normal, respectively). It is proposed that enhanced RBC/EC adherence may contribute to the microcirculatory disorders observed in thalassaemia, especially in TI patients who are particularly known to suffer from leg ulcers.
AB - The adherence of red blood cells (RBC) to endothelial cells (EC), shown to correlate with microvascular occlusion in sickle cell disease and malaria, is considered a major contributor to microcirculatory disorders. In the present study the adherence to EC was markedly enhanced with RBC from β- thalassaemia major (TM) patients, and even more so with RBC from β- thalassaemia intermedia (TI) patients (10-fold and 25-fold higher than normal, respectively). It is proposed that enhanced RBC/EC adherence may contribute to the microcirculatory disorders observed in thalassaemia, especially in TI patients who are particularly known to suffer from leg ulcers.
KW - Adhesion
KW - Endothelial cells
KW - Red blood cells
KW - β-thalassaemia intermedia
KW - β-thalassaemia major
UR - http://www.scopus.com/inward/record.url?scp=0032818059&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.1999.01489.x
DO - 10.1046/j.1365-2141.1999.01489.x
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C2 - 10444184
AN - SCOPUS:0032818059
SN - 0007-1048
VL - 106
SP - 178
EP - 181
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 1
ER -
